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HSPA1L HSPA1L HSPA14 HSPA14 HSPA4L HSPA4L HSPA1A HSPA1A GRPEL2 GRPEL2 HSPH1 HSPH1 HSPA4 HSPA4 TIMM44 TIMM44 HSPA1B HSPA1B HSPA8 HSPA8 HSPA9 HSPA9
"GRPEL2" - GrpE-like 2, mitochondrial (E. coli) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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GRPEL2GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) (225 aa)    
Predicted Functional Partners:
HSPA9
heat shock 70kDa protein 9 (mortalin) (679 aa)
score_image     score_image score_image score_image score_image   0.999
HSPA4
heat shock 70kDa protein 4 (840 aa)
score_image     score_image score_image   score_image   0.995
TIMM44
translocase of inner mitochondrial membrane 44 homolog (yeast); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (452 aa)
      score_image score_image score_image score_image   0.993
HSPA4L
heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) (839 aa)
score_image     score_image score_image   score_image   0.992
HSPH1
heat shock 105kDa/110kDa protein 1; Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity) (858 aa)
score_image     score_image score_image   score_image   0.991
HSPA1B
heat shock 70kDa protein 1B (641 aa)
score_image     score_image score_image   score_image   0.989
HSPA1A
heat shock 70kDa protein 1A (641 aa)
score_image     score_image score_image   score_image   0.988
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
score_image     score_image score_image   score_image   0.987
HSPA14
heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (509 aa)
score_image     score_image score_image   score_image   0.987
HSPA1L
heat shock 70kDa protein 1-like (641 aa)
score_image     score_image score_image   score_image   0.987
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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