C12orf56 protein (Homo sapiens) - STRING network view

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C12orf56

chromosome 12 open reading frame 56 (462 aa)

Predicted Functional Partners:

DNAH17

0.660

DTWD2

0.566

TULP3

0.506

WDR26

0.480

RASSF3

0.407

XPOT

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf56	DNAH17	ENSP00000329698	ENSP00000374490	chromosome 12 open reading frame 56	dynein, axonemal, heavy chain 17; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	0.660
C12orf56	DTWD2	ENSP00000329698	ENSP00000425048	chromosome 12 open reading frame 56	DTW domain containing 2	0.566
C12orf56	RASSF3	ENSP00000329698	ENSP00000336616	chromosome 12 open reading frame 56	Ras association (RalGDS/AF-6) domain family member 3	0.407
C12orf56	TULP3	ENSP00000329698	ENSP00000380321	chromosome 12 open reading frame 56	tubby like protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis	0.506
C12orf56	WDR26	ENSP00000329698	ENSP00000408108	chromosome 12 open reading frame 56	WD repeat domain 26; May be involved in MAPK pathways	0.480
C12orf56	XPOT	ENSP00000329698	ENSP00000327821	chromosome 12 open reading frame 56	exportin, tRNA; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of [...]	0.405
DNAH17	C12orf56	ENSP00000374490	ENSP00000329698	dynein, axonemal, heavy chain 17; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	chromosome 12 open reading frame 56	0.660
DTWD2	C12orf56	ENSP00000425048	ENSP00000329698	DTW domain containing 2	chromosome 12 open reading frame 56	0.566
RASSF3	C12orf56	ENSP00000336616	ENSP00000329698	Ras association (RalGDS/AF-6) domain family member 3	chromosome 12 open reading frame 56	0.407
TULP3	C12orf56	ENSP00000380321	ENSP00000329698	tubby like protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis	chromosome 12 open reading frame 56	0.506
WDR26	C12orf56	ENSP00000408108	ENSP00000329698	WD repeat domain 26; May be involved in MAPK pathways	chromosome 12 open reading frame 56	0.480
XPOT	C12orf56	ENSP00000327821	ENSP00000329698	exportin, tRNA; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of [...]	chromosome 12 open reading frame 56	0.405

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