DRG1 protein (Homo sapiens) - STRING network view

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DRG1

developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest (367 aa)

Predicted Functional Partners:

ZC3H15

0.999

RWDD1

0.990

UBC

0.988

RWDD4

0.949

DRG2

0.875

STK16

0.854

WDR12

0.743

BRIX1

0.735

SKIL

0.712

DOHH

0.683

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	DOHH	ENSP00000338862	ENSP00000250937	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	0.884
BRIX1	DRG1	ENSP00000338862	ENSP00000329715	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	0.735
BRIX1	DRG2	ENSP00000338862	ENSP00000225729	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death	0.426
BRIX1	UBC	ENSP00000338862	ENSP00000344818	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ubiquitin C	0.509
BRIX1	WDR12	ENSP00000338862	ENSP00000261015	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.998
BRIX1	ZC3H15	ENSP00000338862	ENSP00000338788	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	zinc finger CCCH-type containing 15; Protects DRG1 from proteolytic degradation (By similarity)	0.459
DOHH	BRIX1	ENSP00000250937	ENSP00000338862	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.884
DOHH	DRG1	ENSP00000250937	ENSP00000329715	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	0.683
DOHH	UBC	ENSP00000250937	ENSP00000344818	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	ubiquitin C	0.509
DOHH	WDR12	ENSP00000250937	ENSP00000261015	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.798
DRG1	BRIX1	ENSP00000329715	ENSP00000338862	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.735
DRG1	DOHH	ENSP00000329715	ENSP00000250937	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	0.683
DRG1	DRG2	ENSP00000329715	ENSP00000225729	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death	0.875
DRG1	RWDD1	ENSP00000329715	ENSP00000420357	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity)	0.990
DRG1	RWDD4	ENSP00000329715	ENSP00000388920	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	RWD domain containing 4	0.949
DRG1	SKIL	ENSP00000329715	ENSP00000259119	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	SKI-like oncogene; May have regulatory role in cell division or differentiation in response to extracellular signals	0.712
DRG1	STK16	ENSP00000329715	ENSP00000379964	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	serine/threonine kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins	0.854
DRG1	UBC	ENSP00000329715	ENSP00000344818	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	ubiquitin C	0.988
DRG1	WDR12	ENSP00000329715	ENSP00000261015	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.743
DRG1	ZC3H15	ENSP00000329715	ENSP00000338788	developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest	zinc finger CCCH-type containing 15; Protects DRG1 from proteolytic degradation (By similarity)	0.999

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