node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG10 | CPNE8 | ENSP00000266483 | ENSP00000329748 | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe); Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.605 |
ALG10 | UBC | ENSP00000266483 | ENSP00000344818 | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe); Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol | ubiquitin C | 0.620 |
ALG10B | CPNE8 | ENSP00000310120 | ENSP00000329748 | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast); Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.635 |
ALG10B | UBC | ENSP00000310120 | ENSP00000344818 | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast); Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 | ubiquitin C | 0.483 |
C9orf169 | CPNE8 | ENSP00000351967 | ENSP00000329748 | chromosome 9 open reading frame 169 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.644 |
CPNE8 | ALG10 | ENSP00000329748 | ENSP00000266483 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe); Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol | 0.605 |
CPNE8 | ALG10B | ENSP00000329748 | ENSP00000310120 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast); Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 | 0.635 |
CPNE8 | C9orf169 | ENSP00000329748 | ENSP00000351967 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | chromosome 9 open reading frame 169 | 0.644 |
CPNE8 | HECTD2 | ENSP00000329748 | ENSP00000298068 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | 0.652 |
CPNE8 | LAMTOR2 | ENSP00000329748 | ENSP00000357288 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.644 |
CPNE8 | RALA | ENSP00000329748 | ENSP00000005257 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | 0.483 |
CPNE8 | TCF20 | ENSP00000329748 | ENSP00000352463 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | transcription factor 20 (AR1); Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator | 0.548 |
CPNE8 | TUBA8 | ENSP00000329748 | ENSP00000333326 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | tubulin, alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.477 |
CPNE8 | UBC | ENSP00000329748 | ENSP00000344818 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | ubiquitin C | 0.854 |
CPNE8 | VPS13A | ENSP00000329748 | ENSP00000353422 | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.514 |
HECTD2 | CPNE8 | ENSP00000298068 | ENSP00000329748 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.652 |
HECTD2 | UBC | ENSP00000298068 | ENSP00000344818 | HECT domain containing E3 ubiquitin protein ligase 2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) | ubiquitin C | 0.609 |
LAMTOR2 | CPNE8 | ENSP00000357288 | ENSP00000329748 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.644 |
RALA | CPNE8 | ENSP00000005257 | ENSP00000329748 | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | copine VIII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.483 |
RALA | UBC | ENSP00000005257 | ENSP00000344818 | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | ubiquitin C | 0.878 |