PSMG1 protein (Homo sapiens) - STRING network view

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PSMG1

proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (288 aa)

Predicted Functional Partners:

UBC

0.892

PSMG2

0.849

POMP

0.822

PSMA7

0.728

MX1

0.682

PSMA2

0.656

PSMB9

0.610

DSCR3

0.610

DSCR4

0.608

PPARD

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DSCR3	DSCR4	ENSP00000311399	ENSP00000381921	Down syndrome critical region gene 3	Down syndrome critical region gene 4	0.669
DSCR3	MX1	ENSP00000311399	ENSP00000381599	Down syndrome critical region gene 3	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.561
DSCR3	PSMG1	ENSP00000311399	ENSP00000329915	Down syndrome critical region gene 3	proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.610
DSCR3	UBC	ENSP00000311399	ENSP00000344818	Down syndrome critical region gene 3	ubiquitin C	0.893
DSCR4	DSCR3	ENSP00000381921	ENSP00000311399	Down syndrome critical region gene 4	Down syndrome critical region gene 3	0.669
DSCR4	MX1	ENSP00000381921	ENSP00000381599	Down syndrome critical region gene 4	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.519
DSCR4	PSMG1	ENSP00000381921	ENSP00000329915	Down syndrome critical region gene 4	proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.608
MX1	DSCR3	ENSP00000381599	ENSP00000311399	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Down syndrome critical region gene 3	0.561
MX1	DSCR4	ENSP00000381599	ENSP00000381921	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Down syndrome critical region gene 4	0.519
MX1	PSMA7	ENSP00000381599	ENSP00000359910	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	proteasome (prosome, macropain) subunit, alpha type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cy [...]	0.559
MX1	PSMB9	ENSP00000381599	ENSP00000363993	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.414
MX1	PSMG1	ENSP00000381599	ENSP00000329915	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.682
MX1	UBC	ENSP00000381599	ENSP00000344818	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	ubiquitin C	0.644
POMP	PSMA2	ENSP00000370222	ENSP00000223321	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	proteasome (prosome, macropain) subunit, alpha type, 2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation	0.989
POMP	PSMA7	ENSP00000370222	ENSP00000359910	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	proteasome (prosome, macropain) subunit, alpha type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cy [...]	0.996
POMP	PSMB9	ENSP00000370222	ENSP00000363993	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.944
POMP	PSMG1	ENSP00000370222	ENSP00000329915	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.822
POMP	PSMG2	ENSP00000370222	ENSP00000325919	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	proteasome (prosome, macropain) assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.965
POMP	UBC	ENSP00000370222	ENSP00000344818	proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum	ubiquitin C	0.887
PPARD	PSMG1	ENSP00000310928	ENSP00000329915	peroxisome proliferator-activated receptor delta	proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization	0.576

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