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NMU NMU NPBWR2 NPBWR2 NPW NPW NPBWR1 NPBWR1 NPB NPB OPRM1 OPRM1 NPY NPY OPRD1 OPRD1 SST SST OPRK1 OPRK1 POMC POMC
"NPW" - neuropeptide W in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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protein homology
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Score
NPWneuropeptide W; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30 (165 aa)    
Predicted Functional Partners:
NPBWR1
neuropeptides B/W receptor 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B (328 aa)
        score_image score_image score_image   0.997
NPBWR2
neuropeptides B/W receptor 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (333 aa)
        score_image score_image score_image   0.994
NPB
neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity) (125 aa)
          score_image score_image   0.988
NMU
neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder (174 aa)
          score_image score_image   0.948
POMC
proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
          score_image score_image   0.944
OPRK1
opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions (380 aa)
          score_image score_image   0.943
OPRM1
opioid receptor, mu 1 (493 aa)
          score_image score_image   0.939
OPRD1
opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins (372 aa)
          score_image score_image   0.937
NPY
neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone (97 aa)
          score_image score_image   0.936
SST
somatostatin; Somatostatin inhibits the release of somatotropin (116 aa)
          score_image score_image   0.933
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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