| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARVCF | SLC16A5 | ENSP00000263207 | ENSP00000330141 | armadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.497 |
| ARVCF | SLC26A8 | ENSP00000263207 | ENSP00000347778 | armadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions | solute carrier family 26, member 8; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility | 0.436 |
| GNA14 | SLC16A5 | ENSP00000365807 | ENSP00000330141 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.523 |
| KCNS2 | MRPS7 | ENSP00000287042 | ENSP00000245539 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) | mitochondrial ribosomal protein S7 | 0.555 |
| KCNS2 | SLC16A5 | ENSP00000287042 | ENSP00000330141 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.595 |
| KCNS2 | SLC26A8 | ENSP00000287042 | ENSP00000347778 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) | solute carrier family 26, member 8; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility | 0.478 |
| LPIN2 | SLC16A5 | ENSP00000261596 | ENSP00000330141 | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.454 |
| MRPS7 | KCNS2 | ENSP00000245539 | ENSP00000287042 | mitochondrial ribosomal protein S7 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) | 0.555 |
| MRPS7 | SLC16A5 | ENSP00000245539 | ENSP00000330141 | mitochondrial ribosomal protein S7 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.459 |
| MRPS7 | TOP2A | ENSP00000245539 | ENSP00000411532 | mitochondrial ribosomal protein S7 | topoisomerase (DNA) II alpha 170kDa | 0.580 |
| MRPS7 | TOP2B | ENSP00000245539 | ENSP00000396704 | mitochondrial ribosomal protein S7 | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.576 |
| SLC16A5 | ARVCF | ENSP00000330141 | ENSP00000263207 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | armadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions | 0.497 |
| SLC16A5 | GNA14 | ENSP00000330141 | ENSP00000365807 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.523 |
| SLC16A5 | KCNS2 | ENSP00000330141 | ENSP00000287042 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) | 0.595 |
| SLC16A5 | LPIN2 | ENSP00000330141 | ENSP00000261596 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | 0.454 |
| SLC16A5 | MRPS7 | ENSP00000330141 | ENSP00000245539 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | mitochondrial ribosomal protein S7 | 0.459 |
| SLC16A5 | SLC26A8 | ENSP00000330141 | ENSP00000347778 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | solute carrier family 26, member 8; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility | 0.503 |
| SLC16A5 | SLC4A7 | ENSP00000330141 | ENSP00000295736 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.527 |
| SLC16A5 | SLC5A12 | ENSP00000330141 | ENSP00000379326 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | solute carrier family 5 (sodium/glucose cotransporter), member 12; Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral [...] | 0.616 |
| SLC16A5 | TOP2A | ENSP00000330141 | ENSP00000411532 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | topoisomerase (DNA) II alpha 170kDa | 0.493 |
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