RSRC2 protein (Homo sapiens) - STRING network view

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RSRC2

arginine/serine-rich coiled-coil 2 (434 aa)

Predicted Functional Partners:

CDK5

0.812

SPDYE1

0.508

MITD1

0.470

SRPK2

0.461

SRPK1

0.461

TRIM40

0.414

SLTM

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5	RSRC2	ENSP00000419782	ENSP00000330188	cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...]	arginine/serine-rich coiled-coil 2	0.812
MITD1	RSRC2	ENSP00000289359	ENSP00000330188	MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	arginine/serine-rich coiled-coil 2	0.470
MITD1	SPDYE1	ENSP00000289359	ENSP00000258704	MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	speedy homolog E1 (Xenopus laevis)	0.459
RSRC2	CDK5	ENSP00000330188	ENSP00000419782	arginine/serine-rich coiled-coil 2	cyclin-dependent kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neurona [...]	0.812
RSRC2	MITD1	ENSP00000330188	ENSP00000289359	arginine/serine-rich coiled-coil 2	MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	0.470
RSRC2	SLTM	ENSP00000330188	ENSP00000369887	arginine/serine-rich coiled-coil 2	SAFB-like, transcription modulator	0.405
RSRC2	SPDYE1	ENSP00000330188	ENSP00000258704	arginine/serine-rich coiled-coil 2	speedy homolog E1 (Xenopus laevis)	0.508
RSRC2	SRPK1	ENSP00000330188	ENSP00000362931	arginine/serine-rich coiled-coil 2	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.461
RSRC2	SRPK2	ENSP00000330188	ENSP00000377262	arginine/serine-rich coiled-coil 2	SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...]	0.461
RSRC2	TRIM40	ENSP00000330188	ENSP00000308310	arginine/serine-rich coiled-coil 2	tripartite motif containing 40	0.414
SLTM	RSRC2	ENSP00000369887	ENSP00000330188	SAFB-like, transcription modulator	arginine/serine-rich coiled-coil 2	0.405
SPDYE1	MITD1	ENSP00000258704	ENSP00000289359	speedy homolog E1 (Xenopus laevis)	MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	0.459
SPDYE1	RSRC2	ENSP00000258704	ENSP00000330188	speedy homolog E1 (Xenopus laevis)	arginine/serine-rich coiled-coil 2	0.508
SRPK1	RSRC2	ENSP00000362931	ENSP00000330188	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	arginine/serine-rich coiled-coil 2	0.461
SRPK1	SRPK2	ENSP00000362931	ENSP00000377262	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...]	0.578
SRPK2	RSRC2	ENSP00000377262	ENSP00000330188	SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...]	arginine/serine-rich coiled-coil 2	0.461
SRPK2	SRPK1	ENSP00000377262	ENSP00000362931	SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...]	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.578
TRIM40	RSRC2	ENSP00000308310	ENSP00000330188	tripartite motif containing 40	arginine/serine-rich coiled-coil 2	0.414

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