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STRINGSTRING
DNAJC6 DNAJC6 TPTE2 TPTE2 PRL PRL GPR125 GPR125 GATA2 GATA2 POU6F1 POU6F1 GATA3 GATA3 TENC1 TENC1 TNS1 TNS1 TNS3 TNS3 GAK GAK
"POU6F1" - POU class 6 homeobox 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
POU6F1POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) (301 aa)    
Predicted Functional Partners:
PRL
prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
            score_image   0.828
GATA3
GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ (444 aa)
            score_image   0.814
GATA2
GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ (480 aa)
            score_image   0.743
GPR125
G protein-coupled receptor 125; Orphan receptor (1321 aa)
            score_image   0.577
GAK
cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (1311 aa)
            score_image   0.563
TENC1
tensin like C1 domain containing phosphatase (tensin 2) (1419 aa)
            score_image   0.562
TNS3
tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity) (1445 aa)
            score_image   0.562
TNS1
tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (1735 aa)
            score_image   0.562
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) (913 aa)
            score_image   0.550
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (522 aa)
            score_image   0.550
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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