node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC6 | POU6F1 | ENSP00000378735 | ENSP00000330190 | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.550 |
GAK | POU6F1 | ENSP00000314499 | ENSP00000330190 | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.563 |
GATA2 | GATA3 | ENSP00000345681 | ENSP00000368632 | GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.903 |
GATA2 | POU6F1 | ENSP00000345681 | ENSP00000330190 | GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.743 |
GATA3 | GATA2 | ENSP00000368632 | ENSP00000345681 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ | 0.903 |
GATA3 | POU6F1 | ENSP00000368632 | ENSP00000330190 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.814 |
GPR125 | POU6F1 | ENSP00000334952 | ENSP00000330190 | G protein-coupled receptor 125; Orphan receptor | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.577 |
POU6F1 | DNAJC6 | ENSP00000330190 | ENSP00000378735 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | 0.550 |
POU6F1 | GAK | ENSP00000330190 | ENSP00000314499 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.563 |
POU6F1 | GATA2 | ENSP00000330190 | ENSP00000345681 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ | 0.743 |
POU6F1 | GATA3 | ENSP00000330190 | ENSP00000368632 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.814 |
POU6F1 | GPR125 | ENSP00000330190 | ENSP00000334952 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | G protein-coupled receptor 125; Orphan receptor | 0.577 |
POU6F1 | PRL | ENSP00000330190 | ENSP00000302150 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | 0.828 |
POU6F1 | TENC1 | ENSP00000330190 | ENSP00000319756 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | tensin like C1 domain containing phosphatase (tensin 2) | 0.562 |
POU6F1 | TNS1 | ENSP00000330190 | ENSP00000171887 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton | 0.562 |
POU6F1 | TNS3 | ENSP00000330190 | ENSP00000312143 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity) | 0.562 |
POU6F1 | TPTE2 | ENSP00000330190 | ENSP00000372437 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 | 0.550 |
PRL | POU6F1 | ENSP00000302150 | ENSP00000330190 | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.828 |
TENC1 | POU6F1 | ENSP00000319756 | ENSP00000330190 | tensin like C1 domain containing phosphatase (tensin 2) | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.562 |
TNS1 | POU6F1 | ENSP00000171887 | ENSP00000330190 | tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) | 0.562 |