PLEKHH1 protein (Homo sapiens) - STRING network view

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PLEKHH1

pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 (1364 aa)

Predicted Functional Partners:

SH2D4B

0.596

SH2D4A

0.596

TXNDC11

0.560

C6orf165

0.534

C4orf29

0.533

GPR62

0.512

SDR16C5

0.490

FAM65A

0.489

TMEM229B

0.480

ESF1

0.475

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4orf29	C6orf165	ENSP00000381937	ENSP00000358575	chromosome 4 open reading frame 29	chromosome 6 open reading frame 165	0.663
C4orf29	PLEKHH1	ENSP00000381937	ENSP00000330278	chromosome 4 open reading frame 29	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.533
C4orf29	SDR16C5	ENSP00000381937	ENSP00000307607	chromosome 4 open reading frame 29	short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH	0.537
C6orf165	C4orf29	ENSP00000358575	ENSP00000381937	chromosome 6 open reading frame 165	chromosome 4 open reading frame 29	0.663
C6orf165	PLEKHH1	ENSP00000358575	ENSP00000330278	chromosome 6 open reading frame 165	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.534
C6orf165	SDR16C5	ENSP00000358575	ENSP00000307607	chromosome 6 open reading frame 165	short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH	0.538
ESF1	PLEKHH1	ENSP00000202816	ENSP00000330278	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.475
ESF1	SDR16C5	ENSP00000202816	ENSP00000307607	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH	0.498
FAM65A	PLEKHH1	ENSP00000400099	ENSP00000330278	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.489
FAM65A	SH2D4A	ENSP00000400099	ENSP00000265807	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.597
FAM65A	SH2D4B	ENSP00000400099	ENSP00000345295	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	SH2 domain containing 4B	0.487
GPR62	PLEKHH1	ENSP00000319250	ENSP00000330278	G protein-coupled receptor 62; Orphan receptor	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.512
PLEKHH1	C4orf29	ENSP00000330278	ENSP00000381937	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	chromosome 4 open reading frame 29	0.533
PLEKHH1	C6orf165	ENSP00000330278	ENSP00000358575	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	chromosome 6 open reading frame 165	0.534
PLEKHH1	ESF1	ENSP00000330278	ENSP00000202816	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.475
PLEKHH1	FAM65A	ENSP00000330278	ENSP00000400099	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...]	0.489
PLEKHH1	GPR62	ENSP00000330278	ENSP00000319250	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	G protein-coupled receptor 62; Orphan receptor	0.512
PLEKHH1	SDR16C5	ENSP00000330278	ENSP00000307607	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH	0.490
PLEKHH1	SH2D4A	ENSP00000330278	ENSP00000265807	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function	0.596
PLEKHH1	SH2D4B	ENSP00000330278	ENSP00000345295	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	SH2 domain containing 4B	0.596

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