FAM83F protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

FAM83F

family with sequence similarity 83, member F (500 aa)

Predicted Functional Partners:

PNPLA1

0.725

C22orf29

0.724

LOC284912

0.703

THEM5

0.651

ACER1

0.621

KLHDC7B

0.580

CERS3

0.546

WBP2NL

0.499

ARHGAP40

0.487

STAMBPL1

0.477

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER1	CERS3	ENSP00000301452	ENSP00000284382	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	0.769
ACER1	FAM83F	ENSP00000301452	ENSP00000330432	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)	family with sequence similarity 83, member F	0.621
ACER1	PNPLA1	ENSP00000301452	ENSP00000378072	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)	patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity)	0.456
ARHGAP40	FAM83F	ENSP00000362442	ENSP00000330432	Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)	family with sequence similarity 83, member F	0.487
C22orf29	FAM83F	ENSP00000330596	ENSP00000330432	chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity	family with sequence similarity 83, member F	0.724
C22orf29	KLHDC7B	ENSP00000330596	ENSP00000379034	chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity	kelch domain containing 7B	0.585
C22orf29	LOC284912	ENSP00000330596	ENSP00000471799	chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity	Hypothetical gene supported by BC001801	0.726
C22orf29	WBP2NL	ENSP00000330596	ENSP00000328800	chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity	WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity)	0.507
CERS3	ACER1	ENSP00000284382	ENSP00000301452	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)	0.769
CERS3	FAM83F	ENSP00000284382	ENSP00000330432	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	family with sequence similarity 83, member F	0.546
CERS3	PNPLA1	ENSP00000284382	ENSP00000378072	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity)	0.441
CERS3	THEM5	ENSP00000284382	ENSP00000357807	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	thioesterase superfamily member 5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function	0.425
FAM83F	ACER1	ENSP00000330432	ENSP00000301452	family with sequence similarity 83, member F	alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity)	0.621
FAM83F	ARHGAP40	ENSP00000330432	ENSP00000362442	family with sequence similarity 83, member F	Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)	0.487
FAM83F	C22orf29	ENSP00000330432	ENSP00000330596	family with sequence similarity 83, member F	chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity	0.724
FAM83F	CERS3	ENSP00000330432	ENSP00000284382	family with sequence similarity 83, member F	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	0.546
FAM83F	KLHDC7B	ENSP00000330432	ENSP00000379034	family with sequence similarity 83, member F	kelch domain containing 7B	0.580
FAM83F	LOC284912	ENSP00000330432	ENSP00000471799	family with sequence similarity 83, member F	Hypothetical gene supported by BC001801	0.703
FAM83F	PNPLA1	ENSP00000330432	ENSP00000378072	family with sequence similarity 83, member F	patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity)	0.725
FAM83F	STAMBPL1	ENSP00000330432	ENSP00000360992	family with sequence similarity 83, member F	STAM binding protein-like 1; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains	0.477

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