| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APRT | GSR | ENSP00000367615 | ENSP00000221130 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.524 |
| APRT | MT1H | ENSP00000367615 | ENSP00000330587 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | 0.588 |
| APRT | NQO1 | ENSP00000367615 | ENSP00000319788 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | NAD(P)H dehydrogenase, quinone 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis | 0.752 |
| DNAJC1 | MT1H | ENSP00000366179 | ENSP00000330587 | DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity) | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | 0.591 |
| ENSG00000269375 | MT1H | ENSP00000470752 | ENSP00000330587 | Esophagus cancer-related gene-2 interaction susceptibility protein | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | 0.408 |
| ENSG00000269375 | SPINK7 | ENSP00000470752 | ENSP00000274565 | Esophagus cancer-related gene-2 interaction susceptibility protein | serine peptidase inhibitor, Kazal type 7 (putative); Probable serine protease inhibitor | 0.901 |
| GSR | APRT | ENSP00000221130 | ENSP00000367615 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.524 |
| GSR | MT1H | ENSP00000221130 | ENSP00000330587 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | 0.518 |
| GSR | NQO1 | ENSP00000221130 | ENSP00000319788 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | NAD(P)H dehydrogenase, quinone 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis | 0.452 |
| MT1H | APRT | ENSP00000330587 | ENSP00000367615 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.588 |
| MT1H | DNAJC1 | ENSP00000330587 | ENSP00000366179 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity) | 0.591 |
| MT1H | ENSG00000269375 | ENSP00000330587 | ENSP00000470752 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | Esophagus cancer-related gene-2 interaction susceptibility protein | 0.408 |
| MT1H | GSR | ENSP00000330587 | ENSP00000221130 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.518 |
| MT1H | MT4 | ENSP00000330587 | ENSP00000219162 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | metallothionein 4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia | 0.519 |
| MT1H | NQO1 | ENSP00000330587 | ENSP00000319788 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | NAD(P)H dehydrogenase, quinone 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis | 0.686 |
| MT1H | PLA2G2A | ENSP00000330587 | ENSP00000364252 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | phospholipase A2, group IIA (platelets, synovial fluid); Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides | 0.495 |
| MT1H | PTPN1 | ENSP00000330587 | ENSP00000360683 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | protein tyrosine phosphatase, non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion | 0.452 |
| MT1H | SPINK7 | ENSP00000330587 | ENSP00000274565 | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | serine peptidase inhibitor, Kazal type 7 (putative); Probable serine protease inhibitor | 0.820 |
| MT4 | MT1H | ENSP00000219162 | ENSP00000330587 | metallothionein 4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia | metallothionein 1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity) | 0.519 |
| MT4 | NQO1 | ENSP00000219162 | ENSP00000319788 | metallothionein 4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia | NAD(P)H dehydrogenase, quinone 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis | 0.439 |
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