| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C22orf29 | FAM83F | ENSP00000330596 | ENSP00000330432 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | family with sequence similarity 83, member F | 0.724 |
| C22orf29 | FBXO28 | ENSP00000330596 | ENSP00000355827 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | F-box protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity) | 0.473 |
| C22orf29 | GGT5 | ENSP00000330596 | ENSP00000381340 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | 0.406 |
| C22orf29 | H2AFX | ENSP00000330596 | ENSP00000364310 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | 0.570 |
| C22orf29 | KLHDC7B | ENSP00000330596 | ENSP00000379034 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | kelch domain containing 7B | 0.585 |
| C22orf29 | LOC284912 | ENSP00000330596 | ENSP00000471799 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | Hypothetical gene supported by BC001801 | 0.726 |
| C22orf29 | MPST | ENSP00000330596 | ENSP00000380318 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | 0.472 |
| C22orf29 | PIK3IP1 | ENSP00000330596 | ENSP00000215912 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | phosphoinositide-3-kinase interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity (By similarity) | 0.472 |
| C22orf29 | THAP7 | ENSP00000330596 | ENSP00000215742 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | THAP domain containing 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors | 0.457 |
| C22orf29 | WBP2NL | ENSP00000330596 | ENSP00000328800 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.507 |
| FAM83F | C22orf29 | ENSP00000330432 | ENSP00000330596 | family with sequence similarity 83, member F | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.724 |
| FAM83F | KLHDC7B | ENSP00000330432 | ENSP00000379034 | family with sequence similarity 83, member F | kelch domain containing 7B | 0.580 |
| FAM83F | LOC284912 | ENSP00000330432 | ENSP00000471799 | family with sequence similarity 83, member F | Hypothetical gene supported by BC001801 | 0.703 |
| FAM83F | MPST | ENSP00000330432 | ENSP00000380318 | family with sequence similarity 83, member F | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | 0.416 |
| FAM83F | PIK3IP1 | ENSP00000330432 | ENSP00000215912 | family with sequence similarity 83, member F | phosphoinositide-3-kinase interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity (By similarity) | 0.420 |
| FAM83F | THAP7 | ENSP00000330432 | ENSP00000215742 | family with sequence similarity 83, member F | THAP domain containing 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors | 0.412 |
| FAM83F | WBP2NL | ENSP00000330432 | ENSP00000328800 | family with sequence similarity 83, member F | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.499 |
| FBXO28 | C22orf29 | ENSP00000355827 | ENSP00000330596 | F-box protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity) | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.473 |
| GGT5 | C22orf29 | ENSP00000381340 | ENSP00000330596 | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.406 |
| H2AFX | C22orf29 | ENSP00000364310 | ENSP00000330596 | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.570 |
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