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GSG1L GSG1L GCNT1 GCNT1 GCNT2 GCNT2 SERPINC1 SERPINC1 HS3ST4 HS3ST4 HS6ST1 HS6ST1 HS6ST2 HS6ST2 GCNT4 GCNT4 GLCE GLCE UST UST HS6ST3 HS6ST3
"HS3ST4" - heparan sulfate in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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HS3ST4heparan sulfate (glucosamine) 3-O-sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity) (456 aa)    
Predicted Functional Partners:
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity (453 aa)
            score_image   0.874
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2; Forms critical branches in O-glycans (428 aa)
            score_image   0.869
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C (402 aa)
            score_image   0.823
HS6ST3
heparan sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (471 aa)
            score_image   0.706
HS6ST2
heparan sulfate 6-O-sulfotransferase 2 (645 aa)
            score_image   0.653
HS6ST1
heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (411 aa)
            score_image   0.642
GLCE
glucuronic acid epimerase; Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins (617 aa)
            score_image   0.586
UST
uronyl-2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin (406 aa)
            score_image   0.490
GSG1L
GSG1-like; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating (By similarity) (331 aa)
            score_image   0.471
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1 (464 aa)
            score_image   0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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