node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GUK1 | HDDC3 | ENSP00000355689 | ENSP00000330721 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | 0.943 |
GUK1 | NME1 | ENSP00000355689 | ENSP00000013034 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.945 |
GUK1 | NME1-NME2 | ENSP00000355689 | ENSP00000376886 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.944 |
GUK1 | NME2 | ENSP00000355689 | ENSP00000376889 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.946 |
GUK1 | NME3 | ENSP00000355689 | ENSP00000219302 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis | 0.941 |
GUK1 | NME4 | ENSP00000355689 | ENSP00000219479 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | 0.941 |
GUK1 | NME5 | ENSP00000355689 | ENSP00000265191 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | 0.937 |
GUK1 | NME6 | ENSP00000355689 | ENSP00000416658 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis | 0.941 |
GUK1 | NME7 | ENSP00000355689 | ENSP00000356785 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.937 |
GUK1 | PKM | ENSP00000355689 | ENSP00000320171 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | pyruvate kinase, muscle | 0.913 |
HDDC3 | GUK1 | ENSP00000330721 | ENSP00000355689 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | 0.943 |
HDDC3 | NME1 | ENSP00000330721 | ENSP00000013034 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.902 |
HDDC3 | NME1-NME2 | ENSP00000330721 | ENSP00000376886 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.902 |
HDDC3 | NME2 | ENSP00000330721 | ENSP00000376889 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.902 |
HDDC3 | NME3 | ENSP00000330721 | ENSP00000219302 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis | 0.902 |
HDDC3 | NME4 | ENSP00000330721 | ENSP00000219479 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | 0.902 |
HDDC3 | NME5 | ENSP00000330721 | ENSP00000265191 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | 0.902 |
HDDC3 | NME6 | ENSP00000330721 | ENSP00000416658 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis | 0.902 |
HDDC3 | NME7 | ENSP00000330721 | ENSP00000356785 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.902 |
HDDC3 | PKM | ENSP00000330721 | ENSP00000320171 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | pyruvate kinase, muscle | 0.903 |