OPCML protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OPCML

opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact (345 aa)

Predicted Functional Partners:

DNMT1

0.831

ERBB2

0.823

PPFIA3

0.804

PPFIA1

0.802

PRNP

0.685

SORL1

0.564

HSF4

0.563

PID1

0.561

RRAS2

0.510

FAIM2

0.508

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNMT1	OPCML	ENSP00000352516	ENSP00000330862	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.831
ERBB2	OPCML	ENSP00000269571	ENSP00000330862	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...]	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.823
ERBB2	RRAS2	ENSP00000269571	ENSP00000256196	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...]	related RAS viral (r-ras) oncogene homolog 2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion	0.538
FAIM2	OPCML	ENSP00000321951	ENSP00000330862	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.508
HSF4	OPCML	ENSP00000264009	ENSP00000330862	heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.563
HSF4	PID1	ENSP00000264009	ENSP00000375907	heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	phosphotyrosine interaction domain containing 1; Increases proliferation of preadipocytes without affecting adipocytic differentiation	0.660
OPCML	DNMT1	ENSP00000330862	ENSP00000352516	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	0.831
OPCML	ERBB2	ENSP00000330862	ENSP00000269571	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...]	0.823
OPCML	FAIM2	ENSP00000330862	ENSP00000321951	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development	0.508
OPCML	HSF4	ENSP00000330862	ENSP00000264009	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	0.563
OPCML	PID1	ENSP00000330862	ENSP00000375907	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	phosphotyrosine interaction domain containing 1; Increases proliferation of preadipocytes without affecting adipocytic differentiation	0.561
OPCML	PPFIA1	ENSP00000330862	ENSP00000253925	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates	0.802
OPCML	PPFIA3	ENSP00000330862	ENSP00000335614	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates	0.804
OPCML	PRNP	ENSP00000330862	ENSP00000368752	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	prion protein	0.685
OPCML	RRAS2	ENSP00000330862	ENSP00000256196	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	related RAS viral (r-ras) oncogene homolog 2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion	0.510
OPCML	SORL1	ENSP00000330862	ENSP00000260197	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	sortilin-related receptor, L(DLR class) A repeats containing; Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction	0.564
PID1	HSF4	ENSP00000375907	ENSP00000264009	phosphotyrosine interaction domain containing 1; Increases proliferation of preadipocytes without affecting adipocytic differentiation	heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	0.660
PID1	OPCML	ENSP00000375907	ENSP00000330862	phosphotyrosine interaction domain containing 1; Increases proliferation of preadipocytes without affecting adipocytic differentiation	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.561
PPFIA1	OPCML	ENSP00000253925	ENSP00000330862	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates	opioid binding protein/cell adhesion molecule-like; Binds opioids in the presence of acidic lipids; probably involved in cell contact	0.802
PPFIA1	PPFIA3	ENSP00000253925	ENSP00000335614	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates	0.526

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About