Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ENKUR | enkurin, TRPC channel interacting protein; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity) (256 aa) | ||||||||||||
Predicted Functional Partners:
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 | TRPC5 | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion (973 aa) |
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0.770 | |||||||||
 | TRPC1 | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion (759 aa) |
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0.757 | |||||||||
 | TMEM207 | transmembrane protein 207 (146 aa) |
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0.634 | ||||||||||
 | PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (724 aa) |
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0.633 | |||||||||
 | C9orf24 | chromosome 9 open reading frame 24; May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells (262 aa) |
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0.618 | ||||||||||
 | NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export (227 aa) |
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0.590 | ||||||||||
 | CCDC113 | coiled-coil domain containing 113 (377 aa) |
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0.504 | |||||||||
 | MAATS1 | MYCBP/AMY-1-associated, testis expressed 1 (767 aa) |
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0.495 | ||||||||||
 | RIIAD1 | regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 (92 aa) |
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0.485 | ||||||||||
 | C6orf165 | chromosome 6 open reading frame 165 (622 aa) |
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0.485 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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