node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL2 | KCNQ1 | ENSP00000332293 | ENSP00000155840 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | 0.661 |
ASCL2 | PHLDA2 | ENSP00000332293 | ENSP00000319231 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | 0.749 |
ASCL2 | SLC22A18 | ENSP00000332293 | ENSP00000307859 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.662 |
ASCL2 | TSPAN32 | ENSP00000332293 | ENSP00000182290 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | tetraspanin 32 | 0.606 |
ASCL2 | TSSC4 | ENSP00000332293 | ENSP00000331087 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | tumor suppressing subtransferable candidate 4 | 0.565 |
KCNQ1 | ASCL2 | ENSP00000155840 | ENSP00000332293 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.661 |
KCNQ1 | PHLDA2 | ENSP00000155840 | ENSP00000319231 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | 0.755 |
KCNQ1 | SLC22A18 | ENSP00000155840 | ENSP00000307859 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.688 |
KCNQ1 | TRPM5 | ENSP00000155840 | ENSP00000155858 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | transient receptor potential cation channel, subfamily M, member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+) [...] | 0.478 |
KCNQ1 | TSPAN32 | ENSP00000155840 | ENSP00000182290 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | tetraspanin 32 | 0.495 |
KCNQ1 | TSSC4 | ENSP00000155840 | ENSP00000331087 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | tumor suppressing subtransferable candidate 4 | 0.660 |
KPNA3 | SETDB2 | ENSP00000261667 | ENSP00000326477 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis | 0.400 |
KPNA3 | TSSC4 | ENSP00000261667 | ENSP00000331087 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | tumor suppressing subtransferable candidate 4 | 0.590 |
NAP1L5 | PHLDA2 | ENSP00000320488 | ENSP00000319231 | nucleosome assembly protein 1-like 5 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | 0.629 |
NAP1L5 | TSSC4 | ENSP00000320488 | ENSP00000331087 | nucleosome assembly protein 1-like 5 | tumor suppressing subtransferable candidate 4 | 0.654 |
PHLDA2 | ASCL2 | ENSP00000319231 | ENSP00000332293 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.749 |
PHLDA2 | KCNQ1 | ENSP00000319231 | ENSP00000155840 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | 0.755 |
PHLDA2 | NAP1L5 | ENSP00000319231 | ENSP00000320488 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | nucleosome assembly protein 1-like 5 | 0.629 |
PHLDA2 | SLC22A18 | ENSP00000319231 | ENSP00000307859 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.814 |
PHLDA2 | TSPAN32 | ENSP00000319231 | ENSP00000182290 | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | tetraspanin 32 | 0.681 |