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STRINGSTRING
WDR70 WDR70 KPNA3 KPNA3 SETDB2 SETDB2 TSSC4 TSSC4 TSPAN32 TSPAN32 SLC22A18 SLC22A18 TRPM5 TRPM5 KCNQ1 KCNQ1 ASCL2 ASCL2 PHLDA2 PHLDA2 NAP1L5 NAP1L5
"TSSC4" - tumor suppressing subtransferable candidate 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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protein homology
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Score
TSSC4tumor suppressing subtransferable candidate 4 (329 aa)    
Predicted Functional Partners:
TSPAN32
tetraspanin 32 (320 aa)
            score_image   0.862
PHLDA2
pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) (152 aa)
            score_image   0.785
TRPM5
transient receptor potential cation channel, subfamily M, member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+) [...] (1165 aa)
            score_image   0.746
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] (676 aa)
            score_image   0.660
NAP1L5
nucleosome assembly protein 1-like 5 (182 aa)
            score_image   0.654
WDR70
WD repeat domain 70 (654 aa)
        score_image       0.644
SETDB2
SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (719 aa)
            score_image   0.627
KPNA3
karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] (521 aa)
        score_image       0.590
ASCL2
achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system (193 aa)
            score_image   0.565
SLC22A18
solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (424 aa)
            score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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