Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
H326 H326 PEX2 PEX2 PEX13 PEX13 PEX14 PEX14 PEX3 PEX3 PEX12 PEX12 PEX19 PEX19 PEX5 PEX5 PEX26 PEX26 PEX1 PEX1 PEX6 PEX6
"PEX26" - peroxisomal biogenesis factor 26 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PEX26peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (305 aa)    
Predicted Functional Partners:
PEX6
peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (980 aa)
        score_image score_image score_image   0.998
PEX1
peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (1283 aa)
        score_image   score_image   0.933
PEX19
peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa)
        score_image   score_image   0.927
PEX3
peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (373 aa)
        score_image   score_image   0.895
H326
DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (751 aa)
            score_image   0.836
PEX14
peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 (377 aa)
            score_image   0.796
PEX5
peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa)
      score_image     score_image   0.779
PEX12
peroxisomal biogenesis factor 12; Required for protein import into peroxisomes (359 aa)
            score_image   0.767
PEX2
peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes (305 aa)
            score_image   0.766
PEX13
peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (403 aa)
            score_image   0.765
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (22%)