CD8B protein (Homo sapiens) - STRING network view

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CD8B

CD8b molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity) (243 aa)

Predicted Functional Partners:

CD8A

0.996

B2M

0.975

CD3D

0.966

CD3G

0.943

CD4

0.932

IL2RB

0.916

CD28

0.913

IL2

0.912

LCK

0.910

CD3E

0.905

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CD28	ENSP00000452780	ENSP00000324890	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD28 molecule	0.904
B2M	CD3D	ENSP00000452780	ENSP00000300692	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.925
B2M	CD3E	ENSP00000452780	ENSP00000354566	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.920
B2M	CD3G	ENSP00000452780	ENSP00000431445	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.925
B2M	CD4	ENSP00000452780	ENSP00000011653	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	0.725
B2M	CD8A	ENSP00000452780	ENSP00000283635	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.998
B2M	CD8B	ENSP00000452780	ENSP00000331172	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD8b molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity)	0.975
B2M	IL2	ENSP00000452780	ENSP00000226730	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells	0.948
B2M	IL2RB	ENSP00000452780	ENSP00000216223	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2	0.908
B2M	LCK	ENSP00000452780	ENSP00000337825	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	lymphocyte-specific protein tyrosine kinase	0.923
CD28	B2M	ENSP00000324890	ENSP00000452780	CD28 molecule	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.904
CD28	CD3D	ENSP00000324890	ENSP00000300692	CD28 molecule	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.916
CD28	CD3E	ENSP00000324890	ENSP00000354566	CD28 molecule	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.907
CD28	CD3G	ENSP00000324890	ENSP00000431445	CD28 molecule	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.908
CD28	CD4	ENSP00000324890	ENSP00000011653	CD28 molecule	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	0.756
CD28	CD8A	ENSP00000324890	ENSP00000283635	CD28 molecule	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.956
CD28	CD8B	ENSP00000324890	ENSP00000331172	CD28 molecule	CD8b molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity)	0.913
CD28	IL2	ENSP00000324890	ENSP00000226730	CD28 molecule	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells	0.910
CD28	LCK	ENSP00000324890	ENSP00000337825	CD28 molecule	lymphocyte-specific protein tyrosine kinase	0.994
CD3D	B2M	ENSP00000300692	ENSP00000452780	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.925

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