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STRINGSTRING
DNAJB6 DNAJB6 HSP90AA1 HSP90AA1 HSP90AB1 HSP90AB1 DNAJC24 DNAJC24 DNAJC10 DNAJC10 GRPEL2 GRPEL2 CLPB CLPB ANKRD45 ANKRD45 DNAJB9 DNAJB9 GRPEL1 GRPEL1 DNAJB7 DNAJB7
"ANKRD45" - ankyrin repeat domain 45 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANKRD45ankyrin repeat domain 45 (266 aa)    
Predicted Functional Partners:
GRPEL2
GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) (225 aa)
score_image     score_image score_image   score_image   0.986
GRPEL1
GrpE-like 1, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (217 aa)
score_image     score_image score_image   score_image   0.986
CLPB
ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process (707 aa)
score_image     score_image score_image   score_image   0.945
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10 (793 aa)
score_image     score_image score_image   score_image   0.864
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7; Probably acts as a co-chaperone (By similarity) (309 aa)
score_image     score_image score_image   score_image   0.788
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) (223 aa)
score_image     score_image score_image   score_image   0.782
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (854 aa)
      score_image score_image   score_image   0.781
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6 (326 aa)
score_image     score_image score_image   score_image   0.780
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (724 aa)
      score_image score_image   score_image   0.779
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24; Stimulates the ATPase activity of several Hsp70-type chaperones (By similarity) (149 aa)
score_image     score_image score_image   score_image   0.776
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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