node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD45 | CLPB | ENSP00000331268 | ENSP00000294053 | ankyrin repeat domain 45 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.945 |
ANKRD45 | DNAJB6 | ENSP00000331268 | ENSP00000262177 | ankyrin repeat domain 45 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.780 |
ANKRD45 | DNAJB7 | ENSP00000331268 | ENSP00000307197 | ankyrin repeat domain 45 | DnaJ (Hsp40) homolog, subfamily B, member 7; Probably acts as a co-chaperone (By similarity) | 0.788 |
ANKRD45 | DNAJB9 | ENSP00000331268 | ENSP00000249356 | ankyrin repeat domain 45 | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | 0.782 |
ANKRD45 | DNAJC10 | ENSP00000331268 | ENSP00000264065 | ankyrin repeat domain 45 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.864 |
ANKRD45 | DNAJC24 | ENSP00000331268 | ENSP00000417548 | ankyrin repeat domain 45 | DnaJ (Hsp40) homolog, subfamily C, member 24; Stimulates the ATPase activity of several Hsp70-type chaperones (By similarity) | 0.776 |
ANKRD45 | GRPEL1 | ENSP00000331268 | ENSP00000264954 | ankyrin repeat domain 45 | GrpE-like 1, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins | 0.986 |
ANKRD45 | GRPEL2 | ENSP00000331268 | ENSP00000329558 | ankyrin repeat domain 45 | GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) | 0.986 |
ANKRD45 | HSP90AA1 | ENSP00000331268 | ENSP00000335153 | ankyrin repeat domain 45 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.781 |
ANKRD45 | HSP90AB1 | ENSP00000331268 | ENSP00000325875 | ankyrin repeat domain 45 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.779 |
CLPB | ANKRD45 | ENSP00000294053 | ENSP00000331268 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | ankyrin repeat domain 45 | 0.945 |
CLPB | DNAJB6 | ENSP00000294053 | ENSP00000262177 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.726 |
CLPB | DNAJB7 | ENSP00000294053 | ENSP00000307197 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily B, member 7; Probably acts as a co-chaperone (By similarity) | 0.726 |
CLPB | DNAJB9 | ENSP00000294053 | ENSP00000249356 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily B, member 9; Acts as a co-chaperone with an Hsp70 protein (By similarity) | 0.726 |
CLPB | DNAJC10 | ENSP00000294053 | ENSP00000264065 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.725 |
CLPB | DNAJC24 | ENSP00000294053 | ENSP00000417548 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily C, member 24; Stimulates the ATPase activity of several Hsp70-type chaperones (By similarity) | 0.697 |
CLPB | GRPEL1 | ENSP00000294053 | ENSP00000264954 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | GrpE-like 1, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins | 0.840 |
CLPB | GRPEL2 | ENSP00000294053 | ENSP00000329558 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) | 0.840 |
CLPB | HSP90AA1 | ENSP00000294053 | ENSP00000335153 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.975 |
CLPB | HSP90AB1 | ENSP00000294053 | ENSP00000325875 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.956 |