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ZNF165 ZNF165 RPS6KA1 RPS6KA1 UBR5 UBR5 TOB2 TOB2 CHAF1A CHAF1A PABPC1 PABPC1 CNOT7 CNOT7 CPEB3 CPEB3 PAN2 PAN2 CNOT8 CNOT8
"TOB2" - transducer of ERBB2, 2 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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TOB2transducer of ERBB2, 2; Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases (344 aa)    
Predicted Functional Partners:
CNOT7
CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] (285 aa)
        score_image   score_image   0.925
PABPC1
poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa)
        score_image   score_image   0.841
CNOT8
CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] (292 aa)
        score_image   score_image   0.633
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein (1202 aa)
        score_image   score_image   0.631
CPEB3
cytoplasmic polyadenylation element binding protein 3 (698 aa)
        score_image   score_image   0.612
CHAF1A
chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] (956 aa)
        score_image   score_image   0.581
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1 (744 aa)
        score_image       0.576
UBR5
ubiquitin protein ligase E3 component n-recognin 5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA da [...] (2799 aa)
        score_image   score_image   0.572
ZNF165
zinc finger protein 165; May be involved in transcriptional regulation (485 aa)
            score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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