node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHD1 | RAB11A | ENSP00000320516 | ENSP00000261890 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.561 |
EHD1 | RAB11FIP1 | ENSP00000320516 | ENSP00000331342 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB11 family interacting protein 1 (class I); A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis | 0.800 |
EHD1 | RAB11FIP2 | ENSP00000320516 | ENSP00000347839 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB11 family interacting protein 2 (class I); A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity | 0.990 |
EHD1 | RAB11FIP3 | ENSP00000320516 | ENSP00000262305 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB11 family interacting protein 3 (class II) | 0.800 |
EHD1 | RAB11FIP4 | ENSP00000320516 | ENSP00000312837 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.800 |
EHD1 | RAB4A | ENSP00000320516 | ENSP00000355651 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.429 |
EHD1 | UBC | ENSP00000320516 | ENSP00000344818 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | ubiquitin C | 0.812 |
PSD | RAB11A | ENSP00000020673 | ENSP00000261890 | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.624 |
PSD | RAB11FIP1 | ENSP00000020673 | ENSP00000331342 | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | RAB11 family interacting protein 1 (class I); A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis | 0.746 |
PSD | RAB11FIP2 | ENSP00000020673 | ENSP00000347839 | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | RAB11 family interacting protein 2 (class I); A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity | 0.747 |
PSD | RAB25 | ENSP00000020673 | ENSP00000354376 | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity) | 0.532 |
PSD | UBC | ENSP00000020673 | ENSP00000344818 | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | ubiquitin C | 0.621 |
RAB11A | EHD1 | ENSP00000261890 | ENSP00000320516 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.561 |
RAB11A | PSD | ENSP00000261890 | ENSP00000020673 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | pleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) | 0.624 |
RAB11A | RAB11B | ENSP00000261890 | ENSP00000333547 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.949 |
RAB11A | RAB11FIP1 | ENSP00000261890 | ENSP00000331342 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 1 (class I); A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis | 0.970 |
RAB11A | RAB11FIP2 | ENSP00000261890 | ENSP00000347839 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 2 (class I); A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity | 0.999 |
RAB11A | RAB11FIP3 | ENSP00000261890 | ENSP00000262305 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 3 (class II) | 0.999 |
RAB11A | RAB11FIP4 | ENSP00000261890 | ENSP00000312837 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.996 |
RAB11A | UBC | ENSP00000261890 | ENSP00000344818 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | ubiquitin C | 0.936 |