| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCR | FES | ENSP00000303507 | ENSP00000331504 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | feline sarcoma oncogene | 0.987 |
| BCR | HSP90AA1 | ENSP00000303507 | ENSP00000335153 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.921 |
| BCR | JAK3 | ENSP00000303507 | ENSP00000391676 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.442 |
| BCR | PIK3R1 | ENSP00000303507 | ENSP00000274335 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.959 |
| DPYSL2 | DPYSL3 | ENSP00000309539 | ENSP00000343690 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | 0.956 |
| DPYSL2 | DPYSL5 | ENSP00000309539 | ENSP00000288699 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | 0.982 |
| DPYSL2 | FES | ENSP00000309539 | ENSP00000331504 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | feline sarcoma oncogene | 0.982 |
| DPYSL2 | PLXNA1 | ENSP00000309539 | ENSP00000377061 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | plexin A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity) | 0.941 |
| DPYSL3 | DPYSL2 | ENSP00000343690 | ENSP00000309539 | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.956 |
| DPYSL3 | DPYSL5 | ENSP00000343690 | ENSP00000288699 | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | 0.964 |
| DPYSL3 | FES | ENSP00000343690 | ENSP00000331504 | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | feline sarcoma oncogene | 0.963 |
| DPYSL3 | PLXNA1 | ENSP00000343690 | ENSP00000377061 | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | plexin A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity) | 0.921 |
| DPYSL5 | DPYSL2 | ENSP00000288699 | ENSP00000309539 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.982 |
| DPYSL5 | DPYSL3 | ENSP00000288699 | ENSP00000343690 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | 0.964 |
| DPYSL5 | FES | ENSP00000288699 | ENSP00000331504 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | feline sarcoma oncogene | 0.963 |
| DPYSL5 | PLXNA1 | ENSP00000288699 | ENSP00000377061 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | plexin A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity) | 0.925 |
| FES | BCR | ENSP00000331504 | ENSP00000303507 | feline sarcoma oncogene | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | 0.987 |
| FES | DPYSL2 | ENSP00000331504 | ENSP00000309539 | feline sarcoma oncogene | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.982 |
| FES | DPYSL3 | ENSP00000331504 | ENSP00000343690 | feline sarcoma oncogene | dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | 0.963 |
| FES | DPYSL5 | ENSP00000331504 | ENSP00000288699 | feline sarcoma oncogene | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | 0.963 |
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