node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTG1 | ENSP00000349960 | ENSP00000331514 | actin, beta | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.943 |
ACTB | CAP2 | ENSP00000349960 | ENSP00000229922 | actin, beta | CAP, adenylate cyclase-associated protein, 2 (yeast); May have a regulatory bifunctional role | 0.944 |
ACTB | CFL1 | ENSP00000349960 | ENSP00000309629 | actin, beta | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.997 |
ACTB | CFL2 | ENSP00000349960 | ENSP00000298159 | actin, beta | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.997 |
ACTB | DSTN | ENSP00000349960 | ENSP00000246069 | actin, beta | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.987 |
ACTB | MYO1A | ENSP00000349960 | ENSP00000300119 | actin, beta | myosin IA; Involved in directing the movement of organelles along actin filaments (Potential) | 0.831 |
ACTB | PLD1 | ENSP00000349960 | ENSP00000342793 | actin, beta | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | 0.936 |
ACTB | UBC | ENSP00000349960 | ENSP00000344818 | actin, beta | ubiquitin C | 0.999 |
ACTB | WASL | ENSP00000349960 | ENSP00000223023 | actin, beta | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.980 |
ACTB | WDR1 | ENSP00000349960 | ENSP00000427687 | actin, beta | WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) | 0.930 |
ACTG1 | ACTB | ENSP00000331514 | ENSP00000349960 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | actin, beta | 0.943 |
ACTG1 | CAP2 | ENSP00000331514 | ENSP00000229922 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | CAP, adenylate cyclase-associated protein, 2 (yeast); May have a regulatory bifunctional role | 0.974 |
ACTG1 | CFL1 | ENSP00000331514 | ENSP00000309629 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.965 |
ACTG1 | CFL2 | ENSP00000331514 | ENSP00000298159 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.985 |
ACTG1 | DSTN | ENSP00000331514 | ENSP00000246069 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.986 |
ACTG1 | MYO1A | ENSP00000331514 | ENSP00000300119 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | myosin IA; Involved in directing the movement of organelles along actin filaments (Potential) | 0.926 |
ACTG1 | PLD1 | ENSP00000331514 | ENSP00000342793 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | 0.891 |
ACTG1 | UBC | ENSP00000331514 | ENSP00000344818 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | ubiquitin C | 0.998 |
ACTG1 | WASL | ENSP00000331514 | ENSP00000223023 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.916 |
ACTG1 | WDR1 | ENSP00000331514 | ENSP00000427687 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) | 0.930 |