| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP10 | CASP8 | ENSP00000286186 | ENSP00000351273 | caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC | caspase 8, apoptosis-related cysteine peptidase | 0.999 |
| CASP10 | TNFAIP8L1 | ENSP00000286186 | ENSP00000331827 | caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.669 |
| CASP8 | CASP10 | ENSP00000351273 | ENSP00000286186 | caspase 8, apoptosis-related cysteine peptidase | caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC | 0.999 |
| CASP8 | TNFAIP8L1 | ENSP00000351273 | ENSP00000331827 | caspase 8, apoptosis-related cysteine peptidase | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.669 |
| DVL3 | PSME3 | ENSP00000316054 | ENSP00000293362 | dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...] | 0.900 |
| DVL3 | TNFAIP8L1 | ENSP00000316054 | ENSP00000331827 | dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.447 |
| FBXW5 | TNFAIP8L1 | ENSP00000313034 | ENSP00000331827 | F-box and WD repeat domain containing 5 | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.812 |
| MCAT | TNFAIP8L1 | ENSP00000290429 | ENSP00000331827 | malonyl CoA-ACP acyltransferase (mitochondrial); Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.478 |
| PAICS | TNFAIP8L1 | ENSP00000382595 | ENSP00000331827 | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.670 |
| POMP | TNFAIP8L1 | ENSP00000370222 | ENSP00000331827 | proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.485 |
| PSME3 | DVL3 | ENSP00000293362 | ENSP00000316054 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...] | dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes | 0.900 |
| PSME3 | TNFAIP8L1 | ENSP00000293362 | ENSP00000331827 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...] | tumor necrosis factor, alpha-induced protein 8-like 1 | 0.607 |
| TNFAIP8L1 | CASP10 | ENSP00000331827 | ENSP00000286186 | tumor necrosis factor, alpha-induced protein 8-like 1 | caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC | 0.669 |
| TNFAIP8L1 | CASP8 | ENSP00000331827 | ENSP00000351273 | tumor necrosis factor, alpha-induced protein 8-like 1 | caspase 8, apoptosis-related cysteine peptidase | 0.669 |
| TNFAIP8L1 | DVL3 | ENSP00000331827 | ENSP00000316054 | tumor necrosis factor, alpha-induced protein 8-like 1 | dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes | 0.447 |
| TNFAIP8L1 | FBXW5 | ENSP00000331827 | ENSP00000313034 | tumor necrosis factor, alpha-induced protein 8-like 1 | F-box and WD repeat domain containing 5 | 0.812 |
| TNFAIP8L1 | MCAT | ENSP00000331827 | ENSP00000290429 | tumor necrosis factor, alpha-induced protein 8-like 1 | malonyl CoA-ACP acyltransferase (mitochondrial); Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias | 0.478 |
| TNFAIP8L1 | PAICS | ENSP00000331827 | ENSP00000382595 | tumor necrosis factor, alpha-induced protein 8-like 1 | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.670 |
| TNFAIP8L1 | POMP | ENSP00000331827 | ENSP00000370222 | tumor necrosis factor, alpha-induced protein 8-like 1 | proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum | 0.485 |
| TNFAIP8L1 | PSME3 | ENSP00000331827 | ENSP00000293362 | tumor necrosis factor, alpha-induced protein 8-like 1 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also b [...] | 0.607 |
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