Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | COL4A5 | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | COL4A2 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1712 aa) |
 |
|
|
|
0.977 | |||||||
 | COL18A1 | collagen, type XVIII, alpha 1 (1519 aa) |
|
|
0.960 | |||||||||
 | COL1A1 | collagen, type I, alpha 1 (1464 aa) |
|
|
|
0.949 | ||||||||
 | COL15A1 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa) |
|
|
0.948 | |||||||||
 | PTK2 | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] (1065 aa) |
|
|
0.946 | |||||||||
 | COL1A2 | collagen, type I, alpha 2 (1366 aa) |
|
|
|
0.945 | ||||||||
 | COL4A6 | collagen, type IV, alpha 6 (1691 aa) |
|
|
|
|
0.935 | |||||||
 | COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa) |
|
|
|
|
0.935 | |||||||
 | COL6A3 | collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa) |
|
|
0.934 | |||||||||
 | COL4A4 | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa) |
|
|
|
0.930 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
