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STRINGSTRING
TTC23L TTC23L ZNF566 ZNF566 ARHGEF28 ARHGEF28 ACTRT1 ACTRT1 ITSN1 ITSN1 WSCD2 WSCD2 ITSN2 ITSN2 NET1 NET1 PGLYRP3 PGLYRP3 ARHGEF3 ARHGEF3 ZC3H7B ZC3H7B
"WSCD2" - WSC domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WSCD2WSC domain containing 2 (565 aa)    
Predicted Functional Partners:
ZNF566
zinc finger protein 566; May be involved in transcriptional regulation (419 aa)
            score_image   0.641
PGLYRP3
peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity (341 aa)
            score_image   0.592
ZC3H7B
zinc finger CCCH-type containing 7B (977 aa)
            score_image   0.588
ARHGEF28
Rho guanine nucleotide exchange factor (GEF) 28; Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity) (1731 aa)
        score_image   score_image   0.584
ITSN1
intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 (1721 aa)
        score_image   score_image   0.584
ITSN2
intersectin 2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR) (1697 aa)
        score_image   score_image   0.584
NET1
neuroepithelial cell transforming 1; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death (596 aa)
        score_image   score_image   0.584
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3 (558 aa)
        score_image   score_image   0.584
TTC23L
tetratricopeptide repeat domain 23-like (361 aa)
            score_image   0.580
ACTRT1
actin-related protein T1 (376 aa)
            score_image   0.543
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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