splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRAMEF1
PRAME family member 1 (474 aa)
Predicted Functional Partners:
ZNF280A
zinc finger protein 280A; May function as a transcription factor (542 aa)
0.508
CBFB
core-binding factor, beta subunit; CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1 (187 aa)
0.472
HSFY2
heat shock transcription factor, Y linked 2 (401 aa)
0.412
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
CBFB
PRAMEF1
ENSP00000415151
ENSP00000332134
core-binding factor, beta subunit; CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1
PRAME family member 1
0.472
HSFY2
PRAMEF1
ENSP00000306549
ENSP00000332134
heat shock transcription factor, Y linked 2
PRAME family member 1
0.412
PRAMEF1
CBFB
ENSP00000332134
ENSP00000415151
PRAME family member 1
core-binding factor, beta subunit; CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1
0.472
PRAMEF1
HSFY2
ENSP00000332134
ENSP00000306549
PRAME family member 1
heat shock transcription factor, Y linked 2
0.412
PRAMEF1
ZNF280A
ENSP00000332134
ENSP00000302855
PRAME family member 1
zinc finger protein 280A; May function as a transcription factor
0.508
ZNF280A
PRAMEF1
ENSP00000302855
ENSP00000332134
zinc finger protein 280A; May function as a transcription factor
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: