| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP4 | DSE | ENSP00000372654 | ENSP00000332151 | aquaporin 4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system | dermatan sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | 0.800 |
| BCAN | CSPG4 | ENSP00000331210 | ENSP00000312506 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | 0.920 |
| BCAN | CSPG5 | ENSP00000331210 | ENSP00000373244 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | 0.911 |
| BCAN | DCN | ENSP00000331210 | ENSP00000052754 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | decorin; May affect the rate of fibrils formation | 0.948 |
| BCAN | DSE | ENSP00000331210 | ENSP00000332151 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | dermatan sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | 0.907 |
| BCAN | NCAN | ENSP00000331210 | ENSP00000252575 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid | 0.921 |
| BCAN | UST | ENSP00000331210 | ENSP00000356433 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | uronyl-2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin | 0.901 |
| BCAN | VCAN | ENSP00000331210 | ENSP00000265077 | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid | 0.919 |
| CSPG4 | BCAN | ENSP00000312506 | ENSP00000331210 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | 0.920 |
| CSPG4 | CSPG5 | ENSP00000312506 | ENSP00000373244 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | 0.906 |
| CSPG4 | DCN | ENSP00000312506 | ENSP00000052754 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | decorin; May affect the rate of fibrils formation | 0.922 |
| CSPG4 | DSE | ENSP00000312506 | ENSP00000332151 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | dermatan sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | 0.900 |
| CSPG4 | NCAN | ENSP00000312506 | ENSP00000252575 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid | 0.926 |
| CSPG4 | UST | ENSP00000312506 | ENSP00000356433 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | uronyl-2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin | 0.900 |
| CSPG4 | VCAN | ENSP00000312506 | ENSP00000265077 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid | 0.936 |
| CSPG5 | BCAN | ENSP00000373244 | ENSP00000331210 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | 0.911 |
| CSPG5 | CSPG4 | ENSP00000373244 | ENSP00000312506 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] | 0.906 |
| CSPG5 | DCN | ENSP00000373244 | ENSP00000052754 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | decorin; May affect the rate of fibrils formation | 0.910 |
| CSPG5 | DSE | ENSP00000373244 | ENSP00000332151 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | dermatan sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | 0.907 |
| CSPG5 | NCAN | ENSP00000373244 | ENSP00000252575 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid | 0.927 |
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