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STRINGSTRING
POMC POMC CXCR4 CXCR4 NPS NPS PMCH PMCH CNR1 CNR1 HCRTR1 HCRTR1 MCHR1 MCHR1 PENK PENK MCHR2 MCHR2 NPY NPY HCRT HCRT
"PMCH" - pro-melanin-concentrating hormone in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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PMCHpro-melanin-concentrating hormone; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation (165 aa)    
Predicted Functional Partners:
MCHR1
melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis (422 aa)
        score_image score_image score_image   0.989
NPY
neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone (97 aa)
        score_image score_image score_image   0.979
MCHR2
melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis (340 aa)
        score_image score_image score_image   0.971
HCRT
hypocretin (orexin) neuropeptide precursor; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (131 aa)
      score_image   score_image score_image   0.967
NPS
neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa)
          score_image score_image   0.964
POMC
proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
          score_image score_image   0.937
PENK
proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum (267 aa)
          score_image score_image   0.936
CXCR4
chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar develo [...] (356 aa)
          score_image score_image   0.936
HCRTR1
hypocretin (orexin) receptor 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity) (425 aa)
          score_image score_image   0.935
CNR1
cannabinoid receptor 1 (brain) (472 aa)
          score_image score_image   0.929
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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