node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | ALDH1A3 | ENSP00000268251 | ENSP00000332256 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.943 |
ABAT | GAD1 | ENSP00000268251 | ENSP00000350928 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.987 |
ACSS1 | ACSS2 | ENSP00000316924 | ENSP00000253382 | acyl-CoA synthetase short-chain family member 1 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.907 |
ACSS1 | ADH1A | ENSP00000316924 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.549 |
ACSS1 | ADH1B | ENSP00000316924 | ENSP00000306606 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.486 |
ACSS1 | ADH4 | ENSP00000316924 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.538 |
ACSS1 | ADH6 | ENSP00000316924 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 6 (class V) | 0.549 |
ACSS1 | ADH7 | ENSP00000316924 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.549 |
ACSS1 | ALDH1A3 | ENSP00000316924 | ENSP00000332256 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.958 |
ACSS2 | ACSS1 | ENSP00000253382 | ENSP00000316924 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | acyl-CoA synthetase short-chain family member 1 | 0.907 |
ACSS2 | ADH1A | ENSP00000253382 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.428 |
ACSS2 | ADH4 | ENSP00000253382 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.423 |
ACSS2 | ADH6 | ENSP00000253382 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 6 (class V) | 0.428 |
ACSS2 | ADH7 | ENSP00000253382 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.428 |
ACSS2 | ALDH1A3 | ENSP00000253382 | ENSP00000332256 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.952 |
ADH1A | ACSS1 | ENSP00000209668 | ENSP00000316924 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.549 |
ADH1A | ACSS2 | ENSP00000209668 | ENSP00000253382 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.428 |
ADH1A | ALDH1A3 | ENSP00000209668 | ENSP00000332256 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.957 |
ADH1B | ACSS1 | ENSP00000306606 | ENSP00000316924 | alcohol dehydrogenase 1B (class I), beta polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.486 |
ADH1B | ALDH1A3 | ENSP00000306606 | ENSP00000332256 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.958 |