| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP5G1 | TRIM69 | ENSP00000348205 | ENSP00000332284 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9); Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is c [...] | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.504 |
| IYD | TRIM69 | ENSP00000229447 | ENSP00000332284 | iodotyrosine deiodinase | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.504 |
| KRT17 | TRIM69 | ENSP00000308452 | ENSP00000332284 | keratin 17 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.504 |
| MAGEA4 | TRIM69 | ENSP00000276344 | ENSP00000332284 | melanoma antigen family A, 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.887 |
| PML | TRIM69 | ENSP00000268058 | ENSP00000332284 | promyelocytic leukemia | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.659 |
| RECK | TRIM69 | ENSP00000367202 | ENSP00000332284 | reversion-inducing-cysteine-rich protein with kazal motifs; Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.472 |
| SF3A3 | TRIM69 | ENSP00000362110 | ENSP00000332284 | splicing factor 3a, subunit 3, 60kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.516 |
| TLR3 | TLR9 | ENSP00000296795 | ENSP00000353874 | toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response | toll-like receptor 9 | 0.934 |
| TLR3 | TRIM69 | ENSP00000296795 | ENSP00000332284 | toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.512 |
| TLR4 | TRIM69 | ENSP00000363089 | ENSP00000332284 | toll-like receptor 4 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.501 |
| TLR9 | TLR3 | ENSP00000353874 | ENSP00000296795 | toll-like receptor 9 | toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response | 0.934 |
| TLR9 | TRIM69 | ENSP00000353874 | ENSP00000332284 | toll-like receptor 9 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | 0.501 |
| TRIM69 | ATP5G1 | ENSP00000332284 | ENSP00000348205 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9); Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is c [...] | 0.504 |
| TRIM69 | IYD | ENSP00000332284 | ENSP00000229447 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | iodotyrosine deiodinase | 0.504 |
| TRIM69 | KRT17 | ENSP00000332284 | ENSP00000308452 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | keratin 17 | 0.504 |
| TRIM69 | MAGEA4 | ENSP00000332284 | ENSP00000276344 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | melanoma antigen family A, 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression | 0.887 |
| TRIM69 | PML | ENSP00000332284 | ENSP00000268058 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | promyelocytic leukemia | 0.659 |
| TRIM69 | RECK | ENSP00000332284 | ENSP00000367202 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | reversion-inducing-cysteine-rich protein with kazal motifs; Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression | 0.472 |
| TRIM69 | SF3A3 | ENSP00000332284 | ENSP00000362110 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | splicing factor 3a, subunit 3, 60kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.516 |
| TRIM69 | TLR3 | ENSP00000332284 | ENSP00000296795 | tripartite motif containing 69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis | toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response | 0.512 |
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