Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TRIM61 | tripartite motif containing 61 (209 aa) | ||||||||||||
Predicted Functional Partners:
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 | BECN1 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus (450 aa) |
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0.575 | ||||||||||
 | OR51Q1 | olfactory receptor, family 51, subfamily Q, member 1; Odorant receptor (Potential) (317 aa) |
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0.538 | ||||||||||
 | C1orf216 | chromosome 1 open reading frame 216 (229 aa) |
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0.532 | ||||||||||
 | KANSL1L | KAT8 regulatory NSL complex subunit 1-like (987 aa) |
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0.504 | ||||||||||
 | UMODL1 | uromodulin-like 1 (1446 aa) |
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0.471 | ||||||||||
 | ZNF558 | zinc finger protein 558 (402 aa) |
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0.457 | ||||||||||
 | CCDC64B | coiled-coil domain containing 64B (508 aa) |
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0.440 | ||||||||||
 | SSRP1 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] (709 aa) |
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0.405 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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