| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCL2 | EGR1 | ENSP00000332293 | ENSP00000239938 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.819 |
| ASCL2 | HAND1 | ENSP00000332293 | ENSP00000231121 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | heart and neural crest derivatives expressed 1; Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5’- NRTCTG-3’ (non-canonical E-box) (By similarity) | 0.665 |
| ASCL2 | ID2 | ENSP00000332293 | ENSP00000234091 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | 0.648 |
| ASCL2 | IGF2R | ENSP00000332293 | ENSP00000349437 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | insulin-like growth factor 2 receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4 | 0.644 |
| ASCL2 | KCNQ1 | ENSP00000332293 | ENSP00000155840 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | 0.661 |
| ASCL2 | KDM4A | ENSP00000332293 | ENSP00000361473 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | lysine (K)-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively | 0.898 |
| ASCL2 | MYOD1 | ENSP00000332293 | ENSP00000250003 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.639 |
| ASCL2 | PHLDA2 | ENSP00000332293 | ENSP00000319231 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | pleckstrin homology-like domain, family A, member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity) | 0.749 |
| ASCL2 | SLC22A18 | ENSP00000332293 | ENSP00000307859 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.662 |
| ASCL2 | SP1 | ENSP00000332293 | ENSP00000329357 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.812 |
| EGR1 | ASCL2 | ENSP00000239938 | ENSP00000332293 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.819 |
| EGR1 | ID2 | ENSP00000239938 | ENSP00000234091 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | 0.872 |
| EGR1 | MYOD1 | ENSP00000239938 | ENSP00000250003 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.843 |
| EGR1 | SP1 | ENSP00000239938 | ENSP00000329357 | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.869 |
| HAND1 | ASCL2 | ENSP00000231121 | ENSP00000332293 | heart and neural crest derivatives expressed 1; Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5’- NRTCTG-3’ (non-canonical E-box) (By similarity) | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.665 |
| HAND1 | MYOD1 | ENSP00000231121 | ENSP00000250003 | heart and neural crest derivatives expressed 1; Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5’- NRTCTG-3’ (non-canonical E-box) (By similarity) | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.843 |
| ID2 | ASCL2 | ENSP00000234091 | ENSP00000332293 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.648 |
| ID2 | EGR1 | ENSP00000234091 | ENSP00000239938 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation | 0.872 |
| ID2 | MYOD1 | ENSP00000234091 | ENSP00000250003 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.842 |
| IGF2R | ASCL2 | ENSP00000349437 | ENSP00000332293 | insulin-like growth factor 2 receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.644 |
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