Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CLCN2 CLCN2 TEN1 TEN1 BEST1 BEST1 CLCN1 CLCN1 ANO1 ANO1 BEST3 BEST3 ANO6 ANO6 CFTR CFTR TTYH3 TTYH3 ANO2 ANO2 TTYH2 TTYH2
"BEST3" - bestrophin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BEST3bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) (668 aa)    
Predicted Functional Partners:
ANO1
anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)
           score_image score_image   0.779
ANO2
anoctamin 2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina (998 aa)
           score_image score_image   0.753
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
           score_image score_image   0.673
CLCN1
chloride channel, voltage-sensitive 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (988 aa)
           score_image score_image   0.664
ANO6
anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (931 aa)
           score_image score_image   0.643
TTYH2
tweety homolog 2 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (534 aa)
           score_image score_image   0.633
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
           score_image score_image   0.597
CLCN2
chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (898 aa)
           score_image score_image   0.593
TEN1
TEN1 telomerase capping complex subunit homolog (S. cerevisiae); Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites (123 aa)
             score_image   0.579
BEST1
bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)
           score_image score_image score_image 0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (46%)