Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ADAT3 | adenosine deaminase, tRNA-specific 3 (351 aa) | ||||||||||||
Predicted Functional Partners:
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 | ADAT2 | adenosine deaminase, tRNA-specific 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity) (191 aa) |
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0.987 | |||||||
 | ADAT1 | adenosine deaminase, tRNA-specific 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala (502 aa) |
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0.924 | ||||||||||
 | ADARB2 | adenosine deaminase, RNA-specific, B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (739 aa) |
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0.710 | ||||||||||
 | TRMT6 | tRNA methyltransferase 6 homolog (S. cerevisiae); Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (497 aa) |
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0.691 | |||||||||
 | ADAR | adenosine deaminase, RNA-specific (1226 aa) |
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0.682 | ||||||||||
 | TRMT61A | tRNA methyltransferase 61 homolog A (S. cerevisiae); Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (289 aa) |
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0.667 | |||||||||
 | NSUN2 | NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (767 aa) |
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0.667 | |||||||||
 | CDA | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (146 aa) |
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0.642 | ||||||||||
 | ADARB1 | adenosine deaminase, RNA-specific, B1 (741 aa) |
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0.640 | ||||||||||
 | PUS3 | pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity) (481 aa) |
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0.623 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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