Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SH3BGR | SH3 domain binding glutamic acid-rich protein (239 aa) | ||||||||||||
Predicted Functional Partners:
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 | HMGN1 | high mobility group nucleosome binding domain 1; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity) (100 aa) |
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0.800 | ||||||||||
 | CNGB1 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (1251 aa) |
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0.755 | ||||||||||
 | DSCR3 | Down syndrome critical region gene 3 (297 aa) |
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0.606 | ||||||||||
 | WDR4 | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit (412 aa) |
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0.579 | ||||||||||
 | PHIP | pleckstrin homology domain interacting protein (1821 aa) |
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0.569 | ||||||||||
 | PDXK | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (312 aa) |
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0.548 | ||||||||||
 | B3GALT5 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor (310 aa) |
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0.513 | ||||||||||
 | LTN1 | listerin E3 ubiquitin protein ligase 1 (1812 aa) |
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0.504 | ||||||||||
 | ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 (795 aa) |
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0.491 | ||||||||||
 | FAM3B | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner (235 aa) |
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0.484 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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