OSBP2 protein (Homo sapiens) - STRING network view

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OSBP2

oxysterol binding protein 2; Binds 7-ketocholesterol (916 aa)

Predicted Functional Partners:

HSCB

0.812

VAPB

0.806

UQCR10

0.804

PRKD1

0.741

PRKD2

0.741

PRKD3

0.741

VAPA

0.698

PLEK

0.606

MOSPD3

0.602

VIM

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSCB	OSBP2	ENSP00000216027	ENSP00000332576	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	oxysterol binding protein 2; Binds 7-ketocholesterol	0.812
HSCB	UQCR10	ENSP00000216027	ENSP00000332887	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	ubiquinol-cytochrome c reductase, complex III subunit X; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity)	0.895
MOSPD3	OSBP2	ENSP00000223054	ENSP00000332576	motile sperm domain containing 3	oxysterol binding protein 2; Binds 7-ketocholesterol	0.602
OSBP2	HSCB	ENSP00000332576	ENSP00000216027	oxysterol binding protein 2; Binds 7-ketocholesterol	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.812
OSBP2	MOSPD3	ENSP00000332576	ENSP00000223054	oxysterol binding protein 2; Binds 7-ketocholesterol	motile sperm domain containing 3	0.602
OSBP2	PLEK	ENSP00000332576	ENSP00000234313	oxysterol binding protein 2; Binds 7-ketocholesterol	pleckstrin; Major protein kinase C substrate of platelets	0.606
OSBP2	PRKD1	ENSP00000332576	ENSP00000333568	oxysterol binding protein 2; Binds 7-ketocholesterol	protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...]	0.741
OSBP2	PRKD2	ENSP00000332576	ENSP00000291281	oxysterol binding protein 2; Binds 7-ketocholesterol	protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...]	0.741
OSBP2	PRKD3	ENSP00000332576	ENSP00000234179	oxysterol binding protein 2; Binds 7-ketocholesterol	protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity)	0.741
OSBP2	UQCR10	ENSP00000332576	ENSP00000332887	oxysterol binding protein 2; Binds 7-ketocholesterol	ubiquinol-cytochrome c reductase, complex III subunit X; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity)	0.804
OSBP2	VAPA	ENSP00000332576	ENSP00000345656	oxysterol binding protein 2; Binds 7-ketocholesterol	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking	0.698
OSBP2	VAPB	ENSP00000332576	ENSP00000417175	oxysterol binding protein 2; Binds 7-ketocholesterol	VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation	0.806
OSBP2	VIM	ENSP00000332576	ENSP00000224237	oxysterol binding protein 2; Binds 7-ketocholesterol	vimentin	0.576
PLEK	OSBP2	ENSP00000234313	ENSP00000332576	pleckstrin; Major protein kinase C substrate of platelets	oxysterol binding protein 2; Binds 7-ketocholesterol	0.606
PLEK	PRKD1	ENSP00000234313	ENSP00000333568	pleckstrin; Major protein kinase C substrate of platelets	protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...]	0.509
PLEK	PRKD2	ENSP00000234313	ENSP00000291281	pleckstrin; Major protein kinase C substrate of platelets	protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...]	0.410
PLEK	PRKD3	ENSP00000234313	ENSP00000234179	pleckstrin; Major protein kinase C substrate of platelets	protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity)	0.499
PRKD1	OSBP2	ENSP00000333568	ENSP00000332576	protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...]	oxysterol binding protein 2; Binds 7-ketocholesterol	0.741
PRKD1	PLEK	ENSP00000333568	ENSP00000234313	protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...]	pleckstrin; Major protein kinase C substrate of platelets	0.509
PRKD2	OSBP2	ENSP00000291281	ENSP00000332576	protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...]	oxysterol binding protein 2; Binds 7-ketocholesterol	0.741

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