C22orf25 protein (Homo sapiens) - STRING network view

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C22orf25

chromosome 22 open reading frame 25 (276 aa)

Predicted Functional Partners:

NUS1

0.646

SCO2

0.644

C2orf18

0.629

RNF212

0.622

LUZP2

0.531

SGSM2

0.499

SLC39A13

0.471

EIF3M

0.457

SLC38A10

0.418

RRP1B

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C22orf25	C2orf18	ENSP00000332721	ENSP00000345528	chromosome 22 open reading frame 25	chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter	0.629
C22orf25	EIF3M	ENSP00000332721	ENSP00000436049	chromosome 22 open reading frame 25	eukaryotic translation initiation factor 3, subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...]	0.457
C22orf25	LUZP2	ENSP00000332721	ENSP00000336817	chromosome 22 open reading frame 25	leucine zipper protein 2	0.531
C22orf25	NUS1	ENSP00000332721	ENSP00000357480	chromosome 22 open reading frame 25	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	0.646
C22orf25	RNF212	ENSP00000332721	ENSP00000389709	chromosome 22 open reading frame 25	ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)	0.622
C22orf25	RRP1B	ENSP00000332721	ENSP00000339145	chromosome 22 open reading frame 25	ribosomal RNA processing 1 homolog B (S. cerevisiae)	0.416
C22orf25	SCO2	ENSP00000332721	ENSP00000252785	chromosome 22 open reading frame 25	SCO2 cytochrome c oxidase assembly protein; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2)	0.644
C22orf25	SGSM2	ENSP00000332721	ENSP00000268989	chromosome 22 open reading frame 25	small G protein signaling modulator 2	0.499
C22orf25	SLC38A10	ENSP00000332721	ENSP00000363891	chromosome 22 open reading frame 25	solute carrier family 38, member 10; Putative sodium-dependent amino acid/proton antiporter (By similarity)	0.418
C22orf25	SLC39A13	ENSP00000332721	ENSP00000354689	chromosome 22 open reading frame 25	solute carrier family 39 (zinc transporter), member 13; Acts as a zinc-influx transporter	0.471
C2orf18	C22orf25	ENSP00000345528	ENSP00000332721	chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter	chromosome 22 open reading frame 25	0.629
C2orf18	NUS1	ENSP00000345528	ENSP00000357480	chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	0.707
EIF3M	C22orf25	ENSP00000436049	ENSP00000332721	eukaryotic translation initiation factor 3, subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...]	chromosome 22 open reading frame 25	0.457
LUZP2	C22orf25	ENSP00000336817	ENSP00000332721	leucine zipper protein 2	chromosome 22 open reading frame 25	0.531
LUZP2	RNF212	ENSP00000336817	ENSP00000389709	leucine zipper protein 2	ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)	0.501
NUS1	C22orf25	ENSP00000357480	ENSP00000332721	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	chromosome 22 open reading frame 25	0.646
NUS1	C2orf18	ENSP00000357480	ENSP00000345528	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter	0.707
RNF212	C22orf25	ENSP00000389709	ENSP00000332721	ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)	chromosome 22 open reading frame 25	0.622
RNF212	LUZP2	ENSP00000389709	ENSP00000336817	ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)	leucine zipper protein 2	0.501
RNF212	SGSM2	ENSP00000389709	ENSP00000268989	ring finger protein 212; Key regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)	small G protein signaling modulator 2	0.420

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