C2orf71 protein (Homo sapiens) - STRING network view

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C2orf71

chromosome 2 open reading frame 71; May play an important role in the development of normal vision (1288 aa)

Predicted Functional Partners:

PDE6G

0.637

FAM161A

0.633

PRCD

0.581

CERKL

0.565

C8orf37

0.539

LEMD3

0.510

PDE6A

0.506

PPP1R3A

0.505

ALMS1

0.505

EYS

0.499

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALMS1	C2orf71	ENSP00000264448	ENSP00000332809	Alstrom syndrome 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	0.505
ALMS1	LEMD3	ENSP00000264448	ENSP00000308369	Alstrom syndrome 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	0.531
ALMS1	PDE6G	ENSP00000264448	ENSP00000328412	Alstrom syndrome 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones	0.505
ALMS1	PPP1R3A	ENSP00000264448	ENSP00000284601	Alstrom syndrome 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	protein phosphatase 1, regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity)	0.514
C2orf71	ALMS1	ENSP00000332809	ENSP00000264448	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	Alstrom syndrome 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	0.505
C2orf71	C8orf37	ENSP00000332809	ENSP00000286688	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	chromosome 8 open reading frame 37	0.539
C2orf71	CERKL	ENSP00000332809	ENSP00000341159	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	ceramide kinase-like	0.565
C2orf71	EYS	ENSP00000332809	ENSP00000424243	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	eyes shut homolog (Drosophila)	0.499
C2orf71	FAM161A	ENSP00000332809	ENSP00000385158	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	family with sequence similarity 161, member A; Involved in ciliogenesis	0.633
C2orf71	LEMD3	ENSP00000332809	ENSP00000308369	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	0.510
C2orf71	PDE6A	ENSP00000332809	ENSP00000255266	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal	0.506
C2orf71	PDE6G	ENSP00000332809	ENSP00000328412	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones	0.637
C2orf71	PPP1R3A	ENSP00000332809	ENSP00000284601	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	protein phosphatase 1, regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity)	0.505
C2orf71	PRCD	ENSP00000332809	ENSP00000465932	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	progressive rod-cone degeneration; Involved in vision	0.581
C8orf37	C2orf71	ENSP00000286688	ENSP00000332809	chromosome 8 open reading frame 37	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	0.539
C8orf37	FAM161A	ENSP00000286688	ENSP00000385158	chromosome 8 open reading frame 37	family with sequence similarity 161, member A; Involved in ciliogenesis	0.501
CERKL	C2orf71	ENSP00000341159	ENSP00000332809	ceramide kinase-like	chromosome 2 open reading frame 71; May play an important role in the development of normal vision	0.565
CERKL	EYS	ENSP00000341159	ENSP00000424243	ceramide kinase-like	eyes shut homolog (Drosophila)	0.580
CERKL	FAM161A	ENSP00000341159	ENSP00000385158	ceramide kinase-like	family with sequence similarity 161, member A; Involved in ciliogenesis	0.471
CERKL	PDE6A	ENSP00000341159	ENSP00000255266	ceramide kinase-like	phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal	0.573

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