node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTBD7 | C9orf174 | ENSP00000335615 | ENSP00000364348 | BTB (POZ) domain containing 7 | chromosome 9 open reading frame 174 | 0.407 |
BTBD7 | ZNF530 | ENSP00000335615 | ENSP00000332861 | BTB (POZ) domain containing 7 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.533 |
C9orf174 | BTBD7 | ENSP00000364348 | ENSP00000335615 | chromosome 9 open reading frame 174 | BTB (POZ) domain containing 7 | 0.407 |
C9orf174 | ZNF530 | ENSP00000364348 | ENSP00000332861 | chromosome 9 open reading frame 174 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.623 |
CAMSAP3 | ZNF530 | ENSP00000416797 | ENSP00000332861 | calmodulin regulated spectrin-associated protein family, member 3; Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.518 |
FBXL19 | ZNF530 | ENSP00000369666 | ENSP00000332861 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.501 |
KDM2A | ZNF530 | ENSP00000432786 | ENSP00000332861 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.501 |
KDM2B | ZNF530 | ENSP00000366271 | ENSP00000332861 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.501 |
LRRN1 | ZNF530 | ENSP00000314901 | ENSP00000332861 | leucine rich repeat neuronal 1 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.551 |
PTPN23 | ZNF530 | ENSP00000265562 | ENSP00000332861 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.565 |
UVSSA | ZNF530 | ENSP00000374501 | ENSP00000332861 | UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to [...] | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.508 |
XRN1 | ZNF530 | ENSP00000264951 | ENSP00000332861 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | 0.543 |
ZNF530 | BTBD7 | ENSP00000332861 | ENSP00000335615 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | BTB (POZ) domain containing 7 | 0.533 |
ZNF530 | C9orf174 | ENSP00000332861 | ENSP00000364348 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | chromosome 9 open reading frame 174 | 0.623 |
ZNF530 | CAMSAP3 | ENSP00000332861 | ENSP00000416797 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | calmodulin regulated spectrin-associated protein family, member 3; Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site | 0.518 |
ZNF530 | FBXL19 | ENSP00000332861 | ENSP00000369666 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF530 | KDM2A | ENSP00000332861 | ENSP00000432786 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF530 | KDM2B | ENSP00000332861 | ENSP00000366271 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF530 | LRRN1 | ENSP00000332861 | ENSP00000314901 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | leucine rich repeat neuronal 1 | 0.551 |
ZNF530 | PTPN23 | ENSP00000332861 | ENSP00000265562 | zinc finger protein 530; May be involved in transcriptional regulation (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.565 |