SLC8A1 protein (Homo sapiens) - STRING network view

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SLC8A1

solute carrier family 8 (sodium/calcium exchanger), member 1 (973 aa)

Predicted Functional Partners:

SLC24A1

0.812

PRKG1

0.800

PRKACG

0.800

PRKACB

0.800

PRKACA

0.800

PRKG2

0.800

PRKX

0.800

CKM

0.800

NUP160

0.780

TRPC3

0.695

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKM	SLC8A1	ENSP00000221476	ENSP00000332931	creatine kinase, muscle; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
NUP160	SLC8A1	ENSP00000367721	ENSP00000332931	nucleoporin 160kDa; Involved in poly(A)+ RNA transport	solute carrier family 8 (sodium/calcium exchanger), member 1	0.780
PRKACA	PRKACB	ENSP00000309591	ENSP00000359719	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	protein kinase, cAMP-dependent, catalytic, beta	0.997
PRKACA	PRKACG	ENSP00000309591	ENSP00000366488	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus	0.955
PRKACA	SLC8A1	ENSP00000309591	ENSP00000332931	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
PRKACB	PRKACA	ENSP00000359719	ENSP00000309591	protein kinase, cAMP-dependent, catalytic, beta	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.997
PRKACB	PRKACG	ENSP00000359719	ENSP00000366488	protein kinase, cAMP-dependent, catalytic, beta	protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus	0.901
PRKACB	SLC8A1	ENSP00000359719	ENSP00000332931	protein kinase, cAMP-dependent, catalytic, beta	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
PRKACG	PRKACA	ENSP00000366488	ENSP00000309591	protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.955
PRKACG	PRKACB	ENSP00000366488	ENSP00000359719	protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus	protein kinase, cAMP-dependent, catalytic, beta	0.901
PRKACG	SLC8A1	ENSP00000366488	ENSP00000332931	protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
PRKG1	SLC8A1	ENSP00000363092	ENSP00000332931	protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...]	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
PRKG1	TRPC3	ENSP00000363092	ENSP00000368966	protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...]	transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion	0.651
PRKG2	SLC8A1	ENSP00000264399	ENSP00000332931	protein kinase, cGMP-dependent, type II	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
PRKX	SLC8A1	ENSP00000262848	ENSP00000332931	protein kinase, X-linked; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation	solute carrier family 8 (sodium/calcium exchanger), member 1	0.800
SLC24A1	SLC8A1	ENSP00000261892	ENSP00000332931	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)	solute carrier family 8 (sodium/calcium exchanger), member 1	0.812
SLC8A1	CKM	ENSP00000332931	ENSP00000221476	solute carrier family 8 (sodium/calcium exchanger), member 1	creatine kinase, muscle; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa	0.800
SLC8A1	NUP160	ENSP00000332931	ENSP00000367721	solute carrier family 8 (sodium/calcium exchanger), member 1	nucleoporin 160kDa; Involved in poly(A)+ RNA transport	0.780
SLC8A1	PRKACA	ENSP00000332931	ENSP00000309591	solute carrier family 8 (sodium/calcium exchanger), member 1	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.800
SLC8A1	PRKACB	ENSP00000332931	ENSP00000359719	solute carrier family 8 (sodium/calcium exchanger), member 1	protein kinase, cAMP-dependent, catalytic, beta	0.800

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