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ITPA ITPA GMPR GMPR GMPR2 GMPR2 AMPD1 AMPD1 GART GART ATIC ATIC AMPD3 AMPD3 IMPDH2 IMPDH2 ADSSL1 ADSSL1 CAD CAD ADSL ADSL
"ADSSL1" - adenylosuccinate synthase like 1 in Homo sapiens
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Predicted Interactions
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ADSSL1adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) (500 aa)    
Predicted Functional Partners:
ADSL
adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis- converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate (484 aa)
score_image   score_image score_image   score_image score_image   0.989
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
score_image     score_image   score_image score_image   0.985
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa)
      score_image score_image score_image score_image   0.979
IMPDH2
IMP (inosine 5’-monophosphate) dehydrogenase 2; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (514 aa)
score_image     score_image   score_image score_image   0.970
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa)
score_image     score_image   score_image score_image   0.969
GMPR
guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (345 aa)
score_image     score_image   score_image score_image   0.944
GMPR2
guanosine monophosphate reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (366 aa)
score_image     score_image   score_image score_image   0.943
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (1010 aa)
score_image     score_image     score_image   0.941
AMPD3
adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism (776 aa)
          score_image score_image   0.932
AMPD1
adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism (780 aa)
          score_image score_image   0.932
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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