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POF1B POF1B SOHLH1 SOHLH1 LHX8 LHX8 NOBOX NOBOX FIGLA FIGLA TCFL5 TCFL5 YBX2 YBX2 RFPL4A RFPL4A GDF9 GDF9 ZP2 ZP2 ZAR1 ZAR1
"FIGLA" - folliculogenesis specific basic helix-loop-helix in Homo sapiens
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FIGLAfolliculogenesis specific basic helix-loop-helix; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian develop [...] (219 aa)    
Predicted Functional Partners:
NOBOX
NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity) (691 aa)
            score_image   0.777
TCFL5
transcription factor-like 5 (basic helix-loop-helix); Putative transcription factor. Isoform 3 may play a role in early spermatogenesis (500 aa)
            score_image   0.771
SOHLH1
spermatogenesis and oogenesis specific basic helix-loop-helix 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development (By similarity) (387 aa)
            score_image   0.758
YBX2
Y box binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] (364 aa)
            score_image   0.754
POF1B
premature ovarian failure, 1B; May be involved in ovary development (589 aa)
            score_image   0.748
LHX8
LIM homeobox 8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity) (356 aa)
            score_image   0.734
GDF9
growth differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells (454 aa)
            score_image   0.713
ZP2
zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (745 aa)
            score_image   0.702
RFPL4A
ret finger protein-like 4A (287 aa)
            score_image   0.588
ZAR1
zygote arrest 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity) (424 aa)
            score_image   0.586
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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