node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EWSR1 | NR4A3 | ENSP00000400142 | ENSP00000333122 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | nuclear receptor subfamily 4, group A, member 3 | 0.661 |
EWSR1 | TAF15 | ENSP00000400142 | ENSP00000466950 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II) | 0.662 |
EWSR1 | TCF12 | ENSP00000400142 | ENSP00000331057 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.513 |
EWSR1 | TFG | ENSP00000400142 | ENSP00000240851 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | TRK-fused gene | 0.719 |
GCH1 | NR4A3 | ENSP00000378890 | ENSP00000333122 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | nuclear receptor subfamily 4, group A, member 3 | 0.661 |
HIVEP1 | NR4A3 | ENSP00000368698 | ENSP00000333122 | human immunodeficiency virus type I enhancer binding protein 1; This protein specifically binds to the DNA sequence 5’- GGGACTTTCC-3’ which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequ [...] | nuclear receptor subfamily 4, group A, member 3 | 0.805 |
NR4A3 | EWSR1 | ENSP00000333122 | ENSP00000400142 | nuclear receptor subfamily 4, group A, member 3 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | 0.661 |
NR4A3 | GCH1 | ENSP00000333122 | ENSP00000378890 | nuclear receptor subfamily 4, group A, member 3 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.661 |
NR4A3 | HIVEP1 | ENSP00000333122 | ENSP00000368698 | nuclear receptor subfamily 4, group A, member 3 | human immunodeficiency virus type I enhancer binding protein 1; This protein specifically binds to the DNA sequence 5’- GGGACTTTCC-3’ which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequ [...] | 0.805 |
NR4A3 | PSMC1 | ENSP00000333122 | ENSP00000261303 | nuclear receptor subfamily 4, group A, member 3 | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | 0.804 |
NR4A3 | PSMD2 | ENSP00000333122 | ENSP00000310129 | nuclear receptor subfamily 4, group A, member 3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins | 0.804 |
NR4A3 | SIX3 | ENSP00000333122 | ENSP00000260653 | nuclear receptor subfamily 4, group A, member 3 | SIX homeobox 3; May be involved in visual system development | 0.865 |
NR4A3 | STX17 | ENSP00000333122 | ENSP00000259400 | nuclear receptor subfamily 4, group A, member 3 | syntaxin 17; SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediat [...] | 0.750 |
NR4A3 | TAF15 | ENSP00000333122 | ENSP00000466950 | nuclear receptor subfamily 4, group A, member 3 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II) | 0.750 |
NR4A3 | TCF12 | ENSP00000333122 | ENSP00000331057 | nuclear receptor subfamily 4, group A, member 3 | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.687 |
NR4A3 | TFG | ENSP00000333122 | ENSP00000240851 | nuclear receptor subfamily 4, group A, member 3 | TRK-fused gene | 0.681 |
PSMC1 | NR4A3 | ENSP00000261303 | ENSP00000333122 | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | nuclear receptor subfamily 4, group A, member 3 | 0.804 |
PSMC1 | PSMD2 | ENSP00000261303 | ENSP00000310129 | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins | 0.999 |
PSMD2 | NR4A3 | ENSP00000310129 | ENSP00000333122 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins | nuclear receptor subfamily 4, group A, member 3 | 0.804 |
PSMD2 | PSMC1 | ENSP00000310129 | ENSP00000261303 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins | proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex | 0.999 |