LAMP1 protein (Homo sapiens) - STRING network view

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Score

LAMP1

lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis (417 aa)

Predicted Functional Partners:

CD8A

0.949

NCAM1

0.928

EGFR

0.905

RAB5A

0.881

CD63

0.861

RAB7A

0.855

EEA1

0.840

IL21

0.836

LAPTM5

0.834

CIDEB

0.832

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD63	CD8A	ENSP00000257857	ENSP00000283635	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.472
CD63	EEA1	ENSP00000257857	ENSP00000317955	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	0.668
CD63	LAMP1	ENSP00000257857	ENSP00000333298	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis	0.861
CD63	LAPTM5	ENSP00000257857	ENSP00000294507	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells	0.687
CD63	RAB5A	ENSP00000257857	ENSP00000273047	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension	0.566
CD63	RAB7A	ENSP00000257857	ENSP00000265062	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.536
CD8A	CD63	ENSP00000283635	ENSP00000257857	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	0.472
CD8A	CIDEB	ENSP00000283635	ENSP00000258807	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	cell death-inducing DFFA-like effector b; Activates apoptosis	0.414
CD8A	EGFR	ENSP00000283635	ENSP00000275493	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	epidermal growth factor receptor	0.508
CD8A	IL21	ENSP00000283635	ENSP00000264497	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	interleukin 21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation	0.659
CD8A	LAMP1	ENSP00000283635	ENSP00000333298	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis	0.949
CD8A	NCAM1	ENSP00000283635	ENSP00000318472	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	neural cell adhesion molecule 1	0.909
CIDEB	CD8A	ENSP00000258807	ENSP00000283635	cell death-inducing DFFA-like effector b; Activates apoptosis	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.414
CIDEB	LAMP1	ENSP00000258807	ENSP00000333298	cell death-inducing DFFA-like effector b; Activates apoptosis	lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis	0.832
EEA1	CD63	ENSP00000317955	ENSP00000257857	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	0.668
EEA1	EGFR	ENSP00000317955	ENSP00000275493	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	epidermal growth factor receptor	0.896
EEA1	LAMP1	ENSP00000317955	ENSP00000333298	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis	0.840
EEA1	RAB5A	ENSP00000317955	ENSP00000273047	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension	0.999
EEA1	RAB7A	ENSP00000317955	ENSP00000265062	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.802
EGFR	CD8A	ENSP00000275493	ENSP00000283635	epidermal growth factor receptor	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.508

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