node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK1 | USP45 | ENSP00000378699 | ENSP00000333376 | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | ubiquitin specific peptidase 45 | 0.740 |
CORO1C | MYH10 | ENSP00000261401 | ENSP00000269243 | coronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | 0.487 |
CORO1C | USP45 | ENSP00000261401 | ENSP00000333376 | coronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) | ubiquitin specific peptidase 45 | 0.748 |
MYH10 | CORO1C | ENSP00000269243 | ENSP00000261401 | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | coronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) | 0.487 |
MYH10 | MYL6 | ENSP00000269243 | ENSP00000446714 | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | myosin, light chain 6, alkali, smooth muscle and non-muscle; Regulatory light chain of myosin. Does not bind calcium | 0.943 |
MYH10 | USP45 | ENSP00000269243 | ENSP00000333376 | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | ubiquitin specific peptidase 45 | 0.764 |
MYL6 | MYH10 | ENSP00000446714 | ENSP00000269243 | myosin, light chain 6, alkali, smooth muscle and non-muscle; Regulatory light chain of myosin. Does not bind calcium | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | 0.943 |
MYL6 | USP45 | ENSP00000446714 | ENSP00000333376 | myosin, light chain 6, alkali, smooth muscle and non-muscle; Regulatory light chain of myosin. Does not bind calcium | ubiquitin specific peptidase 45 | 0.740 |
PIK3CG | USP45 | ENSP00000352121 | ENSP00000333376 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukoc [...] | ubiquitin specific peptidase 45 | 0.740 |
RALY | RBMX | ENSP00000246194 | ENSP00000359645 | RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)); Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity) | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | 0.908 |
RALY | USP45 | ENSP00000246194 | ENSP00000333376 | RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)); Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity) | ubiquitin specific peptidase 45 | 0.753 |
RBMX | RALY | ENSP00000359645 | ENSP00000246194 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)); Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity) | 0.908 |
RBMX | RBMXL1 | ENSP00000359645 | ENSP00000318415 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | 0.597 |
RBMX | USP45 | ENSP00000359645 | ENSP00000333376 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | ubiquitin specific peptidase 45 | 0.740 |
RBMXL1 | RBMX | ENSP00000318415 | ENSP00000359645 | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | 0.597 |
RBMXL1 | USP45 | ENSP00000318415 | ENSP00000333376 | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | ubiquitin specific peptidase 45 | 0.740 |
RBMXL1 | YLPM1 | ENSP00000318415 | ENSP00000324463 | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | YLP motif-containing protein 1 ; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation (By similarity) | 0.467 |
TMOD3 | USP45 | ENSP00000308753 | ENSP00000333376 | tropomodulin 3 (ubiquitous); Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity) | ubiquitin specific peptidase 45 | 0.740 |
USP45 | CDK1 | ENSP00000333376 | ENSP00000378699 | ubiquitin specific peptidase 45 | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.740 |
USP45 | CORO1C | ENSP00000333376 | ENSP00000261401 | ubiquitin specific peptidase 45 | coronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) | 0.748 |