TREX2 protein (Homo sapiens) - STRING network view

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TREX2

three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair (236 aa)

Predicted Functional Partners:

PCNA

0.815

ENY2

0.673

WRN

0.660

NXF1

0.645

HAUS7

0.606

MCM3AP

0.587

DNASE1L1

0.579

PCID2

0.542

SHFM1

0.539

ENSG00000258539

0.521

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNASE1L1	TREX2	ENSP00000014935	ENSP00000333441	deoxyribonuclease I-like 1	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.579
ENSG00000258539	TREX2	ENSP00000455755	ENSP00000333441	Uncharacterized protein	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.521
ENY2	MCM3AP	ENSP00000429986	ENSP00000291688	enhancer of yellow 2 homolog (Drosophila); Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and [...]	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	0.997
ENY2	PCID2	ENSP00000429986	ENSP00000337405	enhancer of yellow 2 homolog (Drosophila); Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and [...]	PCI domain containing 2	0.740
ENY2	TREX2	ENSP00000429986	ENSP00000333441	enhancer of yellow 2 homolog (Drosophila); Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and [...]	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.673
HAUS7	TREX2	ENSP00000359239	ENSP00000333441	HAUS augmin-like complex, subunit 7; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.606
MCM3AP	ENY2	ENSP00000291688	ENSP00000429986	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	enhancer of yellow 2 homolog (Drosophila); Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and [...]	0.997
MCM3AP	NXF1	ENSP00000291688	ENSP00000294172	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5	0.817
MCM3AP	PCID2	ENSP00000291688	ENSP00000337405	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	PCI domain containing 2	0.959
MCM3AP	SHFM1	ENSP00000291688	ENSP00000248566	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	split hand/foot malformation (ectrodactyly) type 1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis	0.933
MCM3AP	TREX2	ENSP00000291688	ENSP00000333441	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.587
NXF1	MCM3AP	ENSP00000294172	ENSP00000291688	nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	0.817
NXF1	PCID2	ENSP00000294172	ENSP00000337405	nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5	PCI domain containing 2	0.644
NXF1	TREX2	ENSP00000294172	ENSP00000333441	nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.645
PCID2	ENY2	ENSP00000337405	ENSP00000429986	PCI domain containing 2	enhancer of yellow 2 homolog (Drosophila); Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and [...]	0.740
PCID2	MCM3AP	ENSP00000337405	ENSP00000291688	PCI domain containing 2	minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3	0.959
PCID2	NXF1	ENSP00000337405	ENSP00000294172	PCI domain containing 2	nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5	0.644
PCID2	SHFM1	ENSP00000337405	ENSP00000248566	PCI domain containing 2	split hand/foot malformation (ectrodactyly) type 1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis	0.999
PCID2	TREX2	ENSP00000337405	ENSP00000333441	PCI domain containing 2	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.542
PCNA	TREX2	ENSP00000368438	ENSP00000333441	proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...]	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.815

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