CYP2F1 protein (Homo sapiens) - STRING network view

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CYP2F1

cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine (491 aa)

Predicted Functional Partners:

GSTP1

0.921

EPHX1

0.912

GSTT2B

0.911

GSTM1

0.910

GSTM5

0.910

GSTO2

0.909

MGST1

0.908

GSTT1

0.907

GSTA2

0.906

MGST2

0.903

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP2F1	EPHX1	ENSP00000333534	ENSP00000272167	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	epoxide hydrolase 1, microsomal (xenobiotic)	0.912
CYP2F1	GSTA2	ENSP00000333534	ENSP00000420168	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase alpha 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.906
CYP2F1	GSTM1	ENSP00000333534	ENSP00000311469	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.910
CYP2F1	GSTM5	ENSP00000333534	ENSP00000256593	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.910
CYP2F1	GSTO2	ENSP00000333534	ENSP00000345023	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase omega 2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)	0.909
CYP2F1	GSTP1	ENSP00000333534	ENSP00000381607	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration	0.921
CYP2F1	GSTT1	ENSP00000333534	ENSP00000248935	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide	0.907
CYP2F1	GSTT2B	ENSP00000333534	ENSP00000290765	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity	0.911
CYP2F1	MGST1	ENSP00000333534	ENSP00000010404	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity	0.908
CYP2F1	MGST2	ENSP00000333534	ENSP00000265498	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione	0.903
EPHX1	CYP2F1	ENSP00000272167	ENSP00000333534	epoxide hydrolase 1, microsomal (xenobiotic)	cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine	0.912
EPHX1	GSTA2	ENSP00000272167	ENSP00000420168	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase alpha 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.934
EPHX1	GSTM1	ENSP00000272167	ENSP00000311469	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.974
EPHX1	GSTM5	ENSP00000272167	ENSP00000256593	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles	0.917
EPHX1	GSTO2	ENSP00000272167	ENSP00000345023	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase omega 2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)	0.904
EPHX1	GSTP1	ENSP00000272167	ENSP00000381607	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration	0.971
EPHX1	GSTT1	ENSP00000272167	ENSP00000248935	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide	0.975
EPHX1	GSTT2B	ENSP00000272167	ENSP00000290765	epoxide hydrolase 1, microsomal (xenobiotic)	glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity	0.941
EPHX1	MGST1	ENSP00000272167	ENSP00000010404	epoxide hydrolase 1, microsomal (xenobiotic)	microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity	0.925
EPHX1	MGST2	ENSP00000272167	ENSP00000265498	epoxide hydrolase 1, microsomal (xenobiotic)	microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione	0.906

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